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Polylactic acid-based scaffolds modified by hyaluronic acid

Ulyana V Khomutova 1, 2
Ulyana V Khomutova
, 
Olesya A Laput 2, 3
Olesya A Laput
, 
Alena G Korzhova 2
Alena G Korzhova
, 
Anastasia A Bryuzgina 2
Anastasia A Bryuzgina
, 
Yelena G Shapovalova 2
Yelena G Shapovalova
, 
Yuriy Y Akhmadeev 1
Yuriy Y Akhmadeev
, 
Vladimir Viktorovich Shugurov 1
Vladimir Viktorovich Shugurov
, 
Irina Alexandrovna Kurzina 2, 3
Irina Alexandrovna Kurzina
1 Institute of High Current Electronics, Siberian Branch of the Russian Academy of Sciences, 634055 Tomsk, Russian Federation
2 National Research Tomsk State University, 634050 Tomsk, Russian Federation
3 Surgut State University, 628400 Surgut, Russian Federation
10.71267/mencom.7761
Published 2025-10-21
Communication , Volume 35, Issue 6, 749-751
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Khomutova U. V. et al. Polylactic acid-based scaffolds modified by hyaluronic acid // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 749-751.
GOST all authors (up to 50) Copy
Khomutova U. V., Laput O. A., Korzhova A. G., Bryuzgina A. A., Shapovalova Y. G., Akhmadeev Y. Y., Shugurov V. V., Kurzina I. A. Polylactic acid-based scaffolds modified by hyaluronic acid // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 749-751.
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TY - JOUR
DO - 10.71267/mencom.7761
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7761
TI - Polylactic acid-based scaffolds modified by hyaluronic acid
T2 - Mendeleev Communications
AU - Khomutova, Ulyana V
AU - Laput, Olesya A
AU - Korzhova, Alena G
AU - Bryuzgina, Anastasia A
AU - Shapovalova, Yelena G
AU - Akhmadeev, Yuriy Y
AU - Shugurov, Vladimir Viktorovich
AU - Kurzina, Irina Alexandrovna
PY - 2025
DA - 2025/10/21
PB - Mendeleev Communications
SP - 749-751
IS - 6
VL - 35
ER -
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@article{2025_Khomutova,
author = {Ulyana V Khomutova and Olesya A Laput and Alena G Korzhova and Anastasia A Bryuzgina and Yelena G Shapovalova and Yuriy Y Akhmadeev and Vladimir Viktorovich Shugurov and Irina Alexandrovna Kurzina},
title = {Polylactic acid-based scaffolds modified by hyaluronic acid},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7761},
number = {6},
pages = {749--751},
doi = {10.71267/mencom.7761}
}
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Khomutova, Ulyana V., et al. “Polylactic acid-based scaffolds modified by hyaluronic acid.” Mendeleev Communications, vol. 35, no. 6, Oct. 2025, pp. 749-751. https://mendcomm.colab.ws/publications/10.71267/mencom.7761.

Keywords

electrospinning
hyaluronic acid
low-temperature plasma
macrophages.
nonwoven fibrous materials
polylactic acid
surface properties

Abstract

The effect of two-stage surface modification of polylactic acid (PLA)-based scaffolds, including treatment with a low-temperature nitrogen plasma arc discharge and subsequent immobilization of biologically active molecules of hyaluronic acid, on their physicochemical and biological properties was investigated. It was found that the modification changes the chemical composition of the PLA surface, which contributes to an increase in surface energy and a decrease in the water contact angle. Modification of the PLA surface not only does not lead to the appearance of cytotoxic properties, but, on the contrary, helps to maintain the viability of immune cells on its surface.

Funders

Foundation for Scientific and Technological Development of Yugra
2024-536-05