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5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential

Eugenia Sergeevna Oleynik 1
Eugenia Sergeevna Oleynik
, 
Anna Aleksandrovna Shmarina 1
Anna Aleksandrovna Shmarina
, 
Ekaterina Romanovna Mitina 1
Ekaterina Romanovna Mitina
, 
Ekaterina Alekseevna Mikhina 1
Ekaterina Alekseevna Mikhina
, 
Ilya A Semenov 1
Ilya A Semenov
, 
Ekaterina D Savina 1, 2
Ekaterina D Savina
, 
Lyubov Evgen'evna Grebenkina 1
Lyubov Evgen'evna Grebenkina
, 
Ekaterina Mikhailovna Zhidkova 2
Ekaterina Mikhailovna Zhidkova
, 
Ekaterina A Lesovaya 2, 3, 4
Ekaterina A Lesovaya
,  , 
Olga Nikolaevna Sineva 6
Olga Nikolaevna Sineva
, 
Andrey Valerievich Matveev 1
Andrey Valerievich Matveev
1 M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA -- Russian Technological University, 119571 Moscow, Russian Federation
2 N. N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russian Federation
3 I. P. Pavlov Ryazan State Medical University, 390026 Ryazan, Russian Federation
4 Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation
5 N. F. Gamaleya National Research Center of Epidemiology and Microbiology, 123098 Moscow, Russian Federation
6 G. F. Gause Institute of New Antibiotics, 119021 Moscow, Russian Federation
10.71267/mencom.7753
Published 2025-07-17
Communication , Volume 35, Issue 5, 606-608
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Oleynik E. S. et al. 5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 606-608.
GOST all authors (up to 50) Copy
Oleynik E. S., Shmarina A. A., Mitina E. R., Mikhina E. A., Semenov I. A., Savina E. D., Grebenkina L. E., Zhidkova E. M., Lesovaya E. A., Vetrova E. N., Sineva O. N., Matveev A. V. 5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 606-608.
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TY - JOUR
DO - 10.71267/mencom.7753
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7753
TI - 5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential
T2 - Mendeleev Communications
AU - Oleynik, Eugenia Sergeevna
AU - Shmarina, Anna Aleksandrovna
AU - Mitina, Ekaterina Romanovna
AU - Mikhina, Ekaterina Alekseevna
AU - Semenov, Ilya A
AU - Savina, Ekaterina D
AU - Grebenkina, Lyubov Evgen'evna
AU - Zhidkova, Ekaterina Mikhailovna
AU - Lesovaya, Ekaterina A
AU - Vetrova, Elizaveta Nikolaevna
AU - Sineva, Olga Nikolaevna
AU - Matveev, Andrey Valerievich
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 606-608
IS - 5
VL - 35
ER -
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@article{2025_Oleynik,
author = {Eugenia Sergeevna Oleynik and Anna Aleksandrovna Shmarina and Ekaterina Romanovna Mitina and Ekaterina Alekseevna Mikhina and Ilya A Semenov and Ekaterina D Savina and Lyubov Evgen'evna Grebenkina and Ekaterina Mikhailovna Zhidkova and Ekaterina A Lesovaya and Elizaveta Nikolaevna Vetrova and Olga Nikolaevna Sineva and Andrey Valerievich Matveev},
title = {5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7753},
number = {5},
pages = {606--608},
doi = {10.71267/mencom.7753}
}
MLA
Cite this
MLA Copy
Oleynik, Eugenia Sergeevna, et al. “5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 606-608. https://mendcomm.colab.ws/publications/10.71267/mencom.7753.

Keywords

1
2
4-triazole-3-carboxamides
4-triazole-3-carboxylic acid derivatives
5-(ω-aminoalkyl)-1
acute lymphoblastic leukemia
acyloxalamidrazones
antimicrobial properties.
antiviral agents
chronic myeloid leukemia

Abstract

New homologues of 5-amino-1,2,4-triazole-3-carboxamide, viz., 5-(ω-aminoalkyl)-1,2,4-triazole-3-carboxamides have been synthesized. The intermediate acyloxalamidrazones undergo thermal cyclization to 1,2,4-triazoles with the better yield in the absence of catalyst while in the presence of 10 mol% TsOH the main product is the corresponding 1,3,4-oxadiazole derivative. The obtained compounds have demonstrated various biological properties comparable to those of the nucleoside drug ribavirin.

Funders

Russian Science Foundation
23-25-00382

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