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New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination

Alexey Vladimirovich Trifonov 1
Alexey Vladimirovich Trifonov
, 
Nurbol Orynbasaruly Appazov 2, 3
Nurbol Orynbasaruly Appazov
, 
Roza Khamatkamilovna Bagautdinova 1
Roza Khamatkamilovna Bagautdinova
, 
Ludmila Konstantinovna Kibardina 1
Ludmila Konstantinovna Kibardina
, 
Michael Arkad'evich Pudovik 1
Michael Arkad'evich Pudovik
, 
Anna Pavlovna Lyubina 1
Anna Pavlovna Lyubina
, 
Alexandra Dmitrievna Voloshina 1
Alexandra Dmitrievna Voloshina
, 
Almir Sabirovich Gazizov 1
Almir Sabirovich Gazizov
, 
Aiym E. Tolegen 4
Aiym E. Tolegen
, 
Nurila Abylkaiyr kyzy Togyzbayeva 2
Nurila Abylkaiyr kyzy Togyzbayeva
, 
Klara Khayrolla kyzy Darmagambet 2
Klara Khayrolla kyzy Darmagambet
, 
Rakhymzhan Akhmetkhanovich Turmanov 2, 5
Rakhymzhan Akhmetkhanovich Turmanov
, 
Elena Alexandrovna Chugunova 1
Elena Alexandrovna Chugunova
, 
Alexander Romanovich Burilov 1
Alexander Romanovich Burilov
1 A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, 420088 Kazan, Russian Federation
2 Korkyt Ata Kyzylorda University, 120014 Kyzylorda, Kazakhstan
3 ‘CNEC’ LLP, 120001 Kyzylorda, Kazakhstan
4 Department of Oil, Chemistry and Nanotechnology, Kazan National Research Technological University, 420015 Kazan, Russian Federation
5 ‘DPS Kyzylorda’ LLP, 120008 Kyzylorda, Kazakhstan
10.71267/mencom.7750
Published 2025-07-17
Communication , Volume 35, Issue 5, 537-539
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Trifonov A. V. et al. New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 537-539.
GOST all authors (up to 50) Copy
Trifonov A. V., Appazov N. O., Bagautdinova R. K., Kibardina L. K., Pudovik M. A., Lyubina A. P., Voloshina A. D., Gazizov A. S., Tolegen A. E., Togyzbayeva N. A. K., Darmagambet K. K. K., Turmanov R. A., Chugunova E. A., Burilov A. R. New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 537-539.
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TY - JOUR
DO - 10.71267/mencom.7750
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7750
TI - New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination
T2 - Mendeleev Communications
AU - Trifonov, Alexey Vladimirovich
AU - Appazov, Nurbol Orynbasaruly
AU - Bagautdinova, Roza Khamatkamilovna
AU - Kibardina, Ludmila Konstantinovna
AU - Pudovik, Michael Arkad'evich
AU - Lyubina, Anna Pavlovna
AU - Voloshina, Alexandra Dmitrievna
AU - Gazizov, Almir Sabirovich
AU - Tolegen, Aiym E.
AU - Togyzbayeva, Nurila Abylkaiyr kyzy
AU - Darmagambet, Klara Khayrolla kyzy
AU - Turmanov, Rakhymzhan Akhmetkhanovich
AU - Chugunova, Elena Alexandrovna
AU - Burilov, Alexander Romanovich
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 537-539
IS - 5
VL - 35
ER -
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@article{2025_Trifonov,
author = {Alexey Vladimirovich Trifonov and Nurbol Orynbasaruly Appazov and Roza Khamatkamilovna Bagautdinova and Ludmila Konstantinovna Kibardina and Michael Arkad'evich Pudovik and Anna Pavlovna Lyubina and Alexandra Dmitrievna Voloshina and Almir Sabirovich Gazizov and Aiym E. Tolegen and Nurila Abylkaiyr kyzy Togyzbayeva and Klara Khayrolla kyzy Darmagambet and Rakhymzhan Akhmetkhanovich Turmanov and Elena Alexandrovna Chugunova and Alexander Romanovich Burilov},
title = {New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7750},
number = {5},
pages = {537--539},
doi = {10.71267/mencom.7750}
}
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Trifonov, Alexey Vladimirovich, et al. “New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 537-539. https://mendcomm.colab.ws/publications/10.71267/mencom.7750.

Keywords

azacoumarin
carboxamides
cytotoxicity.
triphenylphosphonium salts
Wittig reaction

Abstract

New phosphonium salts synthesized from 5-chloromethyl-8-methyl-7-azacoumarin-3-carboxamides and triphenylphosphine upon the Wittig reaction with aromatic aldehydes give the corresponding 5-styryl-7-azacoumarin derivatives. The cytotoxic activity of some phosphonium salts against cancer cell lines M-HeLa and HuTu-80 is equal to or superior to that of the reference 5-fluorouracil. The IC50 and SI values of the leading compounds exceed those for 5-fluorouracil by a factor of 3.7 and 2.2, respectively.

Funders

Ministry of Education and Science of the Republic of Kazakhstan
grant no. AP23488720