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One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates

Xin He 1
Xin He
, 
Tian Yuan 1
Tian Yuan
, 
Jie Sui 2
Jie Sui
, 
Shuhan Dong 1
Shuhan Dong
, 
Ziyi Wang 1
Ziyi Wang
, 
Di Liu 1
Di Liu
, 
Yi Zou 3
Yi Zou
1 School of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, 213164 Changzhou, P. R. China
2 Nanjing Customs Testing Center for Dangerous Goods and Packaging, 213100 Changzhou, P. R. China
3 Department of Medicinal Chemistry, China Pharmaceutical University, 210009 Nanjing, P. R. China
10.71267/mencom.7748
Published 2025-07-17
Communication , Volume 35, Issue 5, 530-532
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He X. et al. One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 530-532.
GOST all authors (up to 50) Copy
He X., Yuan T., Sui J., Dong S., Wang Z., Liu D., Zou Y. One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 530-532.
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TY - JOUR
DO - 10.71267/mencom.7748
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7748
TI - One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates
T2 - Mendeleev Communications
AU - He, Xin
AU - Yuan, Tian
AU - Sui, Jie
AU - Dong, Shuhan
AU - Wang, Ziyi
AU - Liu, Di
AU - Zou, Yi
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 530-532
IS - 5
VL - 35
ER -
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@article{2025_He,
author = {Xin He and Tian Yuan and Jie Sui and Shuhan Dong and Ziyi Wang and Di Liu and Yi Zou},
title = {One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7748},
number = {5},
pages = {530--532},
doi = {10.71267/mencom.7748}
}
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He, Xin, et al. “One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 530-532. https://mendcomm.colab.ws/publications/10.71267/mencom.7748.

Keywords

acetylation
acetylisoquinolines
acetylpyridines
acetylquinolines
Claisen condensation
one-pot synthesis
solvent-free process.

Abstract

A convenient one-pot synthesis of acetylated quinolines/isoquinolines/pyridines involves the sodium-promoted Claisen condensation of the corresponding ethyl hetarenecarboxylates with ethyl acetate as the reactant and the solvent. The thus formed intermediate ethyl 3-hetaryl-3-oxopropanoates can be decarboxylated in the same reactor by refluxing with 25% H2SO4 to afford the title products in good to excellent yields.

Funders

Research Fund of Changzhou Vocational Institute of Engineering