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Photoinactivation of the ‘ESKAPE’ group pathogens by N-confused meso-tetrakis(p-sulfonatophenyl)porphyrin tetrasodium salt

Andrey Vladimirovich Kustov 1
Andrey Vladimirovich Kustov
, 
Philipp K. Morshnev 1
Philipp K. Morshnev
, 
2 Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, 153012 Ivanovo, Russian Federation
10.71267/mencom.7734
Published 2025-07-17
Communication , Volume 35, Issue 5, 611-613
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Kustov A. V., Morshnev P. K., Berezin D. B. Photoinactivation of the ‘ESKAPE’ group pathogens by N-confused meso-tetrakis(p-sulfonatophenyl)porphyrin tetrasodium salt // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 611-613.
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Kustov A. V., Morshnev P. K., Berezin D. B. Photoinactivation of the ‘ESKAPE’ group pathogens by N-confused meso-tetrakis(p-sulfonatophenyl)porphyrin tetrasodium salt // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 611-613.
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TY - JOUR
DO - 10.71267/mencom.7734
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7734
TI - Photoinactivation of the ‘ESKAPE’ group pathogens by N-confused meso-tetrakis(p-sulfonatophenyl)porphyrin tetrasodium salt
T2 - Mendeleev Communications
AU - Kustov, Andrey Vladimirovich
AU - Morshnev, Philipp K.
AU - Berezin, Dmitry Borisovich
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 611-613
IS - 5
VL - 35
ER -
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@article{2025_Kustov,
author = {Andrey Vladimirovich Kustov and Philipp K. Morshnev and Dmitry Borisovich Berezin},
title = {Photoinactivation of the ‘ESKAPE’ group pathogens by N-confused meso-tetrakis(p-sulfonatophenyl)porphyrin tetrasodium salt},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7734},
number = {5},
pages = {611--613},
doi = {10.71267/mencom.7734}
}
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Kustov, Andrey Vladimirovich, et al. “Photoinactivation of the ‘ESKAPE’ group pathogens by N-confused meso-tetrakis(p-sulfonatophenyl)porphyrin tetrasodium salt.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 611-613. https://mendcomm.colab.ws/publications/10.71267/mencom.7734.

Keywords

antibiotic resistance
Gram-positive and Gram-negative bacteria
photodynamic inactivation
photosensitizers
porphyrins.
potentiating agents

Abstract

A polyanionic water-soluble N-confused porphyrin photosensitizer containing four p-sulfonatophenyl groups was synthesized, and its behavior was studied in water and aqueous solutions of the micellar surfactant Tween 80. The antimicrobial photodynamic inactivation study indicated that this photosensitizer efficiently killed Staphylococcus aureus; however, Gram-negative pathogens having an outer lipopolysaccharide membrane were relatively resistant to this compound. The potentiation of photodynamic inactivation by addition of appropriate biocompatible agents increasing permeability of the membrane above was successfully tested and briefly discussed.

Funders

Russian Science Foundation
25-23-00037