Home / Publications / Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity

Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity

Olesya V Shabalina 1
Olesya V Shabalina
, 
Dmitrii Andreevich Shabalin 2
Dmitrii Andreevich Shabalin
1 Irkutsk State University, 664003 Irkutsk, Russian Federation
2 A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation
10.71267/mencom.7727
Published 2025-07-17
Communication , Volume 35, Issue 5, 609-610
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Shabalina O. V., Shabalin D. A. Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 609-610.
GOST all authors (up to 50) Copy
Shabalina O. V., Shabalin D. A. Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 609-610.
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TY - JOUR
DO - 10.71267/mencom.7727
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7727
TI - Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity
T2 - Mendeleev Communications
AU - Shabalina, Olesya V
AU - Shabalin, Dmitrii Andreevich
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 609-610
IS - 5
VL - 35
ER -
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@article{2025_Shabalina,
author = {Olesya V Shabalina and Dmitrii Andreevich Shabalin},
title = {Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7727},
number = {5},
pages = {609--610},
doi = {10.71267/mencom.7727}
}
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Shabalina, Olesya V., and Dmitrii Andreevich Shabalin. “Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 609-610. https://mendcomm.colab.ws/publications/10.71267/mencom.7727.

Keywords

3(2H)-furanones
acetylenic ketones
alkynes
radical scavenging activity
vanillin

Abstract

Target-oriented synthesis of highly functionalized 3(2H)-furanone from vanillin through several alkyne intermediates was realized in six steps. The title compound bearing two 4-hydroxy-3-methoxyphenyl moieties showed antiradical activity 1.54 times higher compared to Trolox.