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Synthesis of daidzein derivatives for targeted drug delivery

Alena Igorevna Sidorova 1
Alena Igorevna Sidorova
, 
Vasiliy Sergeevich Koval 1
Vasiliy Sergeevich Koval
, 
Vitalia Victorovna Kulikova 1
Vitalia Victorovna Kulikova
, 
Svetlana Vladimirovna Revtovich 1
Svetlana Vladimirovna Revtovich
, 
Elena Andreevna Morozova 1
Elena Andreevna Morozova
, 
Andrey Aleksandrovich Stomakhin 1
Andrey Aleksandrovich Stomakhin
, 
Natalia Valeryevna Anufrieva 1
Natalia Valeryevna Anufrieva
, 
1 V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russian Federation
10.71267/mencom.7722
Published 2025-05-21
Communication , Volume 35, Issue 4, 454-456
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Sidorova A. I. et al. Synthesis of daidzein derivatives for targeted drug delivery // Mendeleev Communications. 2025. Vol. 35. No. 4. pp. 454-456.
GOST all authors (up to 50) Copy
Sidorova A. I., Koval V. S., Kulikova V. V., Revtovich S. V., Morozova E. A., Stomakhin A. A., Anufrieva N. V., Solyev P. N. Synthesis of daidzein derivatives for targeted drug delivery // Mendeleev Communications. 2025. Vol. 35. No. 4. pp. 454-456.
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TY - JOUR
DO - 10.71267/mencom.7722
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7722
TI - Synthesis of daidzein derivatives for targeted drug delivery
T2 - Mendeleev Communications
AU - Sidorova, Alena Igorevna
AU - Koval, Vasiliy Sergeevich
AU - Kulikova, Vitalia Victorovna
AU - Revtovich, Svetlana Vladimirovna
AU - Morozova, Elena Andreevna
AU - Stomakhin, Andrey Aleksandrovich
AU - Anufrieva, Natalia Valeryevna
AU - Solyev, Pavel Nikolayevich
PY - 2025
DA - 2025/05/21
PB - Mendeleev Communications
SP - 454-456
IS - 4
VL - 35
ER -
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@article{2025_Sidorova,
author = {Alena Igorevna Sidorova and Vasiliy Sergeevich Koval and Vitalia Victorovna Kulikova and Svetlana Vladimirovna Revtovich and Elena Andreevna Morozova and Andrey Aleksandrovich Stomakhin and Natalia Valeryevna Anufrieva and Pavel Nikolayevich Solyev},
title = {Synthesis of daidzein derivatives for targeted drug delivery},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {May},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7722},
number = {4},
pages = {454--456},
doi = {10.71267/mencom.7722}
}
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Cite this
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Sidorova, Alena Igorevna, et al. “Synthesis of daidzein derivatives for targeted drug delivery.” Mendeleev Communications, vol. 35, no. 4, May. 2025, pp. 454-456. https://mendcomm.colab.ws/publications/10.71267/mencom.7722.

Keywords

chromatography-free isolation
daidzein
estrogen receptor α.
isoflavones
Suzuki cross-coupling
targeted drug delivery

Abstract

A new protocol was developed for the synthesis of daidzein derivatives bearing 7-positioned linkers with carboxy and amino functions. The key step of the scheme is the Suzuki cross-coupling, the optimized procedures provide high yields and do not require chromatographic purification. This approach is advantageous for further linker elongation necessary for anchoring and drug-coupling; the compounds obtained are regarded as tumor-directing carriers.

Funders

Russian Science Foundation
20-74-10121-P

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