Keywords
3-carene
6,8-methanobenz[4,5]oxazolo[3,2-a]pyridine
acetone
amino alcohols
cyclohex-2-en-1-one
ethyl trifluoroacetoacetate
monoterpenes
multicomponent reactions
organofluorine compounds
β-pinene
Abstract
The reaction between ethyl trifluoroacetoacetate, acetone and 4-amino-3-hydroxycarane having tertiary hydroxy group affords the 5-hydroxy-5-(trifluoromethyl)cyclohex-2-en-1-one derivative bearing 3-positioned (3-hydroxycaran-4-yl)amino moiety. The analogous reaction with 3-amino-2-hydroxyapopinane having functional groups at the secondary carbon atoms gives the product of further heterocyclization with perhydro 6,8-methanobenz[4,5]oxazolo[3,2-a]pyridine framework.
Funders
Russian Science Foundation
24-13-00427
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