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Trithiacrown ethers incorporating tetrahydropyridine subunit: synthesis, in vitro and in silico studies of inhibitory activity against α-glucosidase

Dat T Nguyen 1
Dat T Nguyen
, 
Nhung Thi Dao 1
Nhung Thi Dao
, 
Van T.T. Tran 1
Van T.T. Tran
, 
Tien Q Le 1
Tien Q Le
, 
Linh M Nguyen 2
Linh M Nguyen
, 
Anh Tuan Le 1
Anh Tuan Le
1 Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 100000 Hanoi, Vietnam
2 Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, 250000 Thai Nguyen, Vietnam
10.71267/mencom.7679
Published 2025-05-21
Communication , Volume 35, Issue 4, 447-449
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Nguyen D. T. et al. Trithiacrown ethers incorporating tetrahydropyridine subunit: synthesis, in vitro and in silico studies of inhibitory activity against α-glucosidase // Mendeleev Communications. 2025. Vol. 35. No. 4. pp. 447-449.
GOST all authors (up to 50) Copy
Nguyen D. T., Dao N. T., Tran V. T., Le T. Q., Nguyen L. M., Le A. T. Trithiacrown ethers incorporating tetrahydropyridine subunit: synthesis, in vitro and in silico studies of inhibitory activity against α-glucosidase // Mendeleev Communications. 2025. Vol. 35. No. 4. pp. 447-449.
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TY - JOUR
DO - 10.71267/mencom.7679
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7679
TI - Trithiacrown ethers incorporating tetrahydropyridine subunit: synthesis, in vitro and in silico studies of inhibitory activity against α-glucosidase
T2 - Mendeleev Communications
AU - Nguyen, Dat T
AU - Dao, Nhung Thi
AU - Tran, Van T.T.
AU - Le, Tien Q
AU - Nguyen, Linh M
AU - Le, Anh Tuan
PY - 2025
DA - 2025/05/21
PB - Mendeleev Communications
SP - 447-449
IS - 4
VL - 35
ER -
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@article{2025_Nguyen,
author = {Dat T Nguyen and Nhung Thi Dao and Van T.T. Tran and Tien Q Le and Linh M Nguyen and Anh Tuan Le},
title = {Trithiacrown ethers incorporating tetrahydropyridine subunit: synthesis, in vitro and in silico studies of inhibitory activity against α-glucosidase},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {May},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7679},
number = {4},
pages = {447--449},
doi = {10.71267/mencom.7679}
}
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Nguyen, Dat T., et al. “Trithiacrown ethers incorporating tetrahydropyridine subunit: synthesis, in vitro and in silico studies of inhibitory activity against α-glucosidase.” Mendeleev Communications, vol. 35, no. 4, May. 2025, pp. 447-449. https://mendcomm.colab.ws/publications/10.71267/mencom.7679.

Keywords

domino reaction
molecular docking study
tetrahydropyridine
trithiacrown ether
α-glucosidase

Abstract

Several novel thiacrown ether derivatives incorpotating tetrahydropyridine subunits have been prepared by the three-component domino reaction of dialdehyde podand, alkyl acetoacetates and ammonium acetate as the nitrogen source. The inhibitory activity of the compounds obtained against α-glucosidase was tested, which revealed two excellent antidiabetic compounds with low IC50 values in comparison with control drug. Docking studies proposed the plausible interaction between the synthesized compounds and α-glucosidase receptor.