Home / Publications / Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors

Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors

, 
Zahra A Ahmedova 1
Zahra A Ahmedova
, 
Maria Aleksandrovna Kolyvanova 1, 2, 3
Maria Aleksandrovna Kolyvanova
, 
Nikita Sergeyevich Lifanovsky 2
Nikita Sergeyevich Lifanovsky
,  , 
Alina Alexandrovna Markova 2
Alina Alexandrovna Markova
, 
Minh Tuan Nguyen 2
Minh Tuan Nguyen
, 
Elena Feofanovna Shevtsova 4
Elena Feofanovna Shevtsova
, 
Konstantin Alexandrovich Lyssenko 1
Konstantin Alexandrovich Lyssenko
,  , 
Vladimir Alexandrovich Kuzmin 2
Vladimir Alexandrovich Kuzmin
, 
Vladimir Nikolaevich Morozov 2
Vladimir Nikolaevich Morozov
, 
Elena Rudol'fovna Milaeva 1, 4
Elena Rudol'fovna Milaeva
1 Department of Chemistry, M.V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
2 N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russian Federation
3 Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency of the Russian Federation, 123098 Moscow, Russian Federation
4 Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation
10.71267/mencom.7671
Published 2025-05-21
Communication , Volume 35, Issue 4, 433-436
Share
Cite this
GOST
 | 
Cite this
GOST Copy
Nikitin E. A. et al. Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors // Mendeleev Communications. 2025. Vol. 35. No. 4. pp. 433-436.
GOST all authors (up to 50) Copy
Nikitin E. A., Ahmedova Z. A., Kolyvanova M. A., Lifanovsky N. S., Belousov A. V., Markova A. A., Nguyen M. T., Shevtsova E. F., Lyssenko K. A., Tyurin V. Y., Kuzmin V. A., Morozov V. N., Milaeva E. R. Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors // Mendeleev Communications. 2025. Vol. 35. No. 4. pp. 433-436.
RIS
 | 
Cite this
RIS Copy
TY - JOUR
DO - 10.71267/mencom.7671
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7671
TI - Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors
T2 - Mendeleev Communications
AU - Nikitin, Evgeny Aleksandrovich
AU - Ahmedova, Zahra A
AU - Kolyvanova, Maria Aleksandrovna
AU - Lifanovsky, Nikita Sergeyevich
AU - Belousov, Alexandr Vital'evich
AU - Markova, Alina Alexandrovna
AU - Nguyen, Minh Tuan
AU - Shevtsova, Elena Feofanovna
AU - Lyssenko, Konstantin Alexandrovich
AU - Tyurin, Vladimir Yuryevich
AU - Kuzmin, Vladimir Alexandrovich
AU - Morozov, Vladimir Nikolaevich
AU - Milaeva, Elena Rudol'fovna
PY - 2025
DA - 2025/05/21
PB - Mendeleev Communications
SP - 433-436
IS - 4
VL - 35
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Nikitin,
author = {Evgeny Aleksandrovich Nikitin and Zahra A Ahmedova and Maria Aleksandrovna Kolyvanova and Nikita Sergeyevich Lifanovsky and Alexandr Vital'evich Belousov and Alina Alexandrovna Markova and Minh Tuan Nguyen and Elena Feofanovna Shevtsova and Konstantin Alexandrovich Lyssenko and Vladimir Yuryevich Tyurin and Vladimir Alexandrovich Kuzmin and Vladimir Nikolaevich Morozov and Elena Rudol'fovna Milaeva},
title = {Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {May},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7671},
number = {4},
pages = {433--436},
doi = {10.71267/mencom.7671}
}
MLA
Cite this
MLA Copy
Nikitin, Evgeny Aleksandrovich, et al. “Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors.” Mendeleev Communications, vol. 35, no. 4, May. 2025, pp. 433-436. https://mendcomm.colab.ws/publications/10.71267/mencom.7671.

Keywords

antioxidants
circular dichroism.
pyridinecarboxamides
radical scavengers
radioprotectors
sterically hindered phenols

Abstract

New compounds consisting of 2,6-di-tert-butylphenol and isomeric pyridinecarboxamide moieties as well as their water-soluble hydrochlorides were synthesized. The compounds appeared to be potent antioxidants and radioprotectors, with no significant difference in activity between the pyridine bases and their salts. The cytotoxicity assay showed no significant toxic impact from any of the substances, making them promising candidates for further investigation.

Funders

Russian Science Foundation
23-23-10030