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Acetals in amidoalkylation of phosphonous carboxylic acids

Sofia Romanovna Golovash 1
Sofia Romanovna Golovash
, 
Dmitry E Ivanov 1
Dmitry E Ivanov
, 
Alexey Vladimirovich Borodachev 1
Alexey Vladimirovich Borodachev
, 
Sergey V Simonov 2
Sergey V Simonov
, 
Maxim E Dmitriev 1
Maxim E Dmitriev
, 
Valery Vladimirovich Ragulin 1
Valery Vladimirovich Ragulin
1 Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation
2 Yu. A. Osipyan Institute of Solid State Physics, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation
10.71267/mencom.7650
Published 2025-03-31
Communication , Volume 35, Issue 3, 266-268
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Golovash S. R. et al. Acetals in amidoalkylation of phosphonous carboxylic acids // Mendeleev Communications. 2025. Vol. 35. No. 3. pp. 266-268.
GOST all authors (up to 50) Copy
Golovash S. R., Ivanov D. E., Borodachev A. V., Simonov S. V., Dmitriev M. E., Ragulin V. V. Acetals in amidoalkylation of phosphonous carboxylic acids // Mendeleev Communications. 2025. Vol. 35. No. 3. pp. 266-268.
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TY - JOUR
DO - 10.71267/mencom.7650
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7650
TI - Acetals in amidoalkylation of phosphonous carboxylic acids
T2 - Mendeleev Communications
AU - Golovash, Sofia Romanovna
AU - Ivanov, Dmitry E
AU - Borodachev, Alexey Vladimirovich
AU - Simonov, Sergey V
AU - Dmitriev, Maxim E
AU - Ragulin, Valery Vladimirovich
PY - 2025
DA - 2025/03/31
PB - Mendeleev Communications
SP - 266-268
IS - 3
VL - 35
ER -
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@article{2025_Golovash,
author = {Sofia Romanovna Golovash and Dmitry E Ivanov and Alexey Vladimirovich Borodachev and Sergey V Simonov and Maxim E Dmitriev and Valery Vladimirovich Ragulin},
title = {Acetals in amidoalkylation of phosphonous carboxylic acids},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7650},
number = {3},
pages = {266--268},
doi = {10.71267/mencom.7650}
}
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Cite this
MLA Copy
Golovash, Sofia Romanovna, et al. “Acetals in amidoalkylation of phosphonous carboxylic acids.” Mendeleev Communications, vol. 35, no. 3, Mar. 2025, pp. 266-268. https://mendcomm.colab.ws/publications/10.71267/mencom.7650.

Keywords

acetals
acyliminium cation
amidoalkylation
Kabachnik�Fields reaction.
phospha lactone
phosphinic pseudopeptides
phosphonous carboxylic diacids

Abstract

The use of free phosphonous carboxylic diacids in three-component carbamate version of the Kabachnik--Fields reaction in acetyl chloride medium allows introducing acetals into the reaction sphere to result in phosphinic peptides. The employment of low-stable and functionally substituted aldehydes in the form of acetals provides phosphinic peptides that are difficult to obtain by other methods.

Funders

Russian Science Foundation
23-23-00158

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