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Synthesis and antitumor activity of bis-camptothecin ester of succinic acid

Nuri Mamedeevich Chobanov 1
Nuri Mamedeevich Chobanov
, 
Lilya Useinovna Dzhemileva 1
Lilya Useinovna Dzhemileva
, 
Konstantin Olegovich Vakhnin 2
Konstantin Olegovich Vakhnin
,  , 
Vladimir Anatol'evich D'yakonov 1
Vladimir Anatol'evich D'yakonov
2 Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation
10.71267/mencom.7641
Published 2025-03-31
Communication , Volume 35, Issue 3, 289-291
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Chobanov N. M. et al. Synthesis and antitumor activity of bis-camptothecin ester of succinic acid // Mendeleev Communications. 2025. Vol. 35. No. 3. pp. 289-291.
GOST all authors (up to 50) Copy
Chobanov N. M., Dzhemileva L. U., Vakhnin K. O., Dzhemilev U. M., D'yakonov V. A. Synthesis and antitumor activity of bis-camptothecin ester of succinic acid // Mendeleev Communications. 2025. Vol. 35. No. 3. pp. 289-291.
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TY - JOUR
DO - 10.71267/mencom.7641
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7641
TI - Synthesis and antitumor activity of bis-camptothecin ester of succinic acid
T2 - Mendeleev Communications
AU - Chobanov, Nuri Mamedeevich
AU - Dzhemileva, Lilya Useinovna
AU - Vakhnin, Konstantin Olegovich
AU - Dzhemilev, Usein Memetovich
AU - D'yakonov, Vladimir Anatol'evich
PY - 2025
DA - 2025/03/31
PB - Mendeleev Communications
SP - 289-291
IS - 3
VL - 35
ER -
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@article{2025_Chobanov,
author = {Nuri Mamedeevich Chobanov and Lilya Useinovna Dzhemileva and Konstantin Olegovich Vakhnin and Usein Memetovich Dzhemilev and Vladimir Anatol'evich D'yakonov},
title = {Synthesis and antitumor activity of bis-camptothecin ester of succinic acid},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7641},
number = {3},
pages = {289--291},
doi = {10.71267/mencom.7641}
}
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Chobanov, Nuri Mamedeevich, et al. “Synthesis and antitumor activity of bis-camptothecin ester of succinic acid.” Mendeleev Communications, vol. 35, no. 3, Mar. 2025, pp. 289-291. https://mendcomm.colab.ws/publications/10.71267/mencom.7641.

Keywords

antitumor activity
apoptosis
camptothecin
cell cycle
cytotoxicity
flow cytometry
hybrid molecules
succinic diester
topoisomerase I inhibitors

Abstract

New succinic diester containing two residues of antitumor alkaloid camptothecin has been synthesized. Its cytotoxicity and effect on cell cycle and induction of apoptosis were explored using modern methods of flow cytometry, as well as in vitro studies of the inhibitory activity against human topoisomerase I.

Funders

Russian Science Foundation
22-13-00160

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