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Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model

Marina N Semenova 1
Marina N Semenova
, 
Victor Petrovich Kislyi 2
Victor Petrovich Kislyi
, 
Anna Sergeevna Maksimenko 2
Anna Sergeevna Maksimenko
, 
Ivan A. Koblov 2
Ivan A. Koblov
, 
Nikita A. Kuznetsov 2
Nikita A. Kuznetsov
, 
Karim Narimanovich Alisultanov 2
Karim Narimanovich Alisultanov
,  ,  , 
Alexander Viktorovich Samet 2
Alexander Viktorovich Samet
, 
Victor Vladimirovich Semenov 1, 2
Victor Vladimirovich Semenov
1 N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation
10.71267/mencom.7633
Published 2025-03-31
Communication , Volume 35, Issue 3, 274-277
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Semenova M. N. et al. Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model // Mendeleev Communications. 2025. Vol. 35. No. 3. pp. 274-277.
GOST all authors (up to 50) Copy
Semenova M. N., Kislyi V. P., Maksimenko A. S., Koblov I. A., Kuznetsov N. A., Alisultanov K. N., Khrustalev V. N., Samigullina A. I., Samet A. V., Semenov V. V. Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model // Mendeleev Communications. 2025. Vol. 35. No. 3. pp. 274-277.
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TY - JOUR
DO - 10.71267/mencom.7633
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7633
TI - Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model
T2 - Mendeleev Communications
AU - Semenova, Marina N
AU - Kislyi, Victor Petrovich
AU - Maksimenko, Anna Sergeevna
AU - Koblov, Ivan A.
AU - Kuznetsov, Nikita A.
AU - Alisultanov, Karim Narimanovich
AU - Khrustalev, Victor Nikolaevich
AU - Samigullina, Aida Ildusovna
AU - Samet, Alexander Viktorovich
AU - Semenov, Victor Vladimirovich
PY - 2025
DA - 2025/03/31
PB - Mendeleev Communications
SP - 274-277
IS - 3
VL - 35
ER -
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@article{2025_Semenova,
author = {Marina N Semenova and Victor Petrovich Kislyi and Anna Sergeevna Maksimenko and Ivan A. Koblov and Nikita A. Kuznetsov and Karim Narimanovich Alisultanov and Victor Nikolaevich Khrustalev and Aida Ildusovna Samigullina and Alexander Viktorovich Samet and Victor Vladimirovich Semenov},
title = {Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7633},
number = {3},
pages = {274--277},
doi = {10.71267/mencom.7633}
}
MLA
Cite this
MLA Copy
Semenova, Marina N., et al. “Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model.” Mendeleev Communications, vol. 35, no. 3, Mar. 2025, pp. 274-277. https://mendcomm.colab.ws/publications/10.71267/mencom.7633.

Keywords

arylnitromethanes
combretastatin
Knoevenagel condensation
microtubule
sea urchin embryo
tubulin
α-nitrostilbenes

Abstract

A series of nitro analogues of potent antimitotic combretastatin A-4 (diaryl α-nitrostilbenes, DNSs) was synthesized by the Knoevenagel condensation of arylnitromethanes with methylamine Schiff bases of benzaldehydes. The obtained stilbenes featured only cis-diaryl topology irrespective of substitution pattern in the aryl fragments. The evaluation on a sea urchin embryo model suggested that DNSs exhibited both antitubulin and tubulin-unrelated effects similar to those of corresponding monoaryl nitrostyrenes.

Funders

Ministry of Education and Science of the Russian Federation
0088-2024-0015

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