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Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids

Sergey Vladislavovich Gladnev 1, 2
Sergey Vladislavovich Gladnev
,  , 
Tat'yana Borisovna Tennikova 2
Tat'yana Borisovna Tennikova
, 
Evgenia Georgievna Korzhikova-Vlakh 1, 2
Evgenia Georgievna Korzhikova-Vlakh
1 Institute of Macromolecular Compounds, Branch of B. P. Konstantinov Petersburg Nuclear Physics Institute of National Research Centre ‘Kurchatov Institute’, 199004 St. Petersburg, Russian Federation
2 Institute of Chemistry, St. Petersburg State University, 198504 St. Petersburg, Russian Federation
10.71267/mencom.7606
Published 2025-03-31
Communication , Volume 35, Issue 3, 295-298
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Gladnev S. V. et al. Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids // Mendeleev Communications. 2025. Vol. 35. No. 3. pp. 295-298.
GOST all authors (up to 50) Copy
Gladnev S. V., Levit M. L., Tennikova T. B., Korzhikova-Vlakh E. G. Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids // Mendeleev Communications. 2025. Vol. 35. No. 3. pp. 295-298.
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TY - JOUR
DO - 10.71267/mencom.7606
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7606
TI - Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids
T2 - Mendeleev Communications
AU - Gladnev, Sergey Vladislavovich
AU - Levit, Mariia Leonidovna
AU - Tennikova, Tat'yana Borisovna
AU - Korzhikova-Vlakh, Evgenia Georgievna
PY - 2025
DA - 2025/03/31
PB - Mendeleev Communications
SP - 295-298
IS - 3
VL - 35
ER -
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@article{2025_Gladnev,
author = {Sergey Vladislavovich Gladnev and Mariia Leonidovna Levit and Tat'yana Borisovna Tennikova and Evgenia Georgievna Korzhikova-Vlakh},
title = {Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7606},
number = {3},
pages = {295--298},
doi = {10.71267/mencom.7606}
}
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Gladnev, Sergey Vladislavovich, et al. “Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids.” Mendeleev Communications, vol. 35, no. 3, Mar. 2025, pp. 295-298. https://mendcomm.colab.ws/publications/10.71267/mencom.7606.
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Keywords

bioinspired copolymers
delivery systems
graft copolymers
metal-free click chemistry
nucleic acids.
polypeptides
synthetic glycopolymers

Abstract

Bioinspired copolymers consisting of a glycopolymer main chain grafted with polylysine were synthesized using metal-free click chemistry based on a 1,3-dipolar cycloaddition reaction involving strained cyclic alkyne. Poly(2-deoxy-2- methacrylamido-d-glucose)-graft-polylysine was efficiently complexed with a double-stranded oligonucleotide duplex. The cytotoxicity of the polyplex was lower than that of the free copolymer.

Funders

Russian Science Foundation
21-73-20104

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