Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity

Zhang, Xia; Fan, Pingping; Wei, Shigui; Du, Yonghong; Li, Jinjing; Shi, Chengyang

doi:10.71267/mencom.7605

Home / Publications / Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity

Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity

Xia Zhang ¹

Xia Zhang

,

Pingping Fan ¹

Pingping Fan

,

Shigui Wei ¹

Shigui Wei

,

Yonghong Du ¹

Yonghong Du

,

Jinjing Li ¹

Jinjing Li

,

Chengyang Shi ¹

Chengyang Shi

¹ College of Pharmacy, Jiamusi University, 154007 Jiamusi, China

10.71267/mencom.7605

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Published 2025-02-18

Communication , Volume 35, Issue 2, 155-157

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Zhang X. et al. Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity // Mendeleev Communications. 2025. Vol. 35. No. 2. pp. 155-157.

GOST all authors (up to 50) Copy

Zhang X., Fan P., Wei S., Du Y., Li J., Shi C. Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity // Mendeleev Communications. 2025. Vol. 35. No. 2. pp. 155-157.

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TY - JOUR

DO - 10.71267/mencom.7605

UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7605

TI - Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity

T2 - Mendeleev Communications

AU - Zhang, Xia

AU - Fan, Pingping

AU - Wei, Shigui

AU - Du, Yonghong

AU - Li, Jinjing

AU - Shi, Chengyang

PY - 2025

DA - 2025/02/18

PB - Mendeleev Communications

SP - 155-157

IS - 2

VL - 35

ER -

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@article{2025_Zhang,

author = {Xia Zhang and Pingping Fan and Shigui Wei and Yonghong Du and Jinjing Li and Chengyang Shi},

title = {Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity},

journal = {Mendeleev Communications},

year = {2025},

volume = {35},

publisher = {Mendeleev Communications},

month = {Feb},

url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7605},

number = {2},

pages = {155--157},

doi = {10.71267/mencom.7605}

}

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Zhang, Xia, et al. “Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity.” Mendeleev Communications, vol. 35, no. 2, Feb. 2025, pp. 155-157. https://mendcomm.colab.ws/publications/10.71267/mencom.7605.

Keywords

1

3-thiazolidine-2

4-diones

antiproliferative activity.

Knoevenagel condensation

MTT method

N-acylation

Abstract

New 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones were prepared by the Knoevenagel condensation of 1,3-thiazolidine-2,4-dione with aromatic aldehydes, conversion of the thus obtained 5-arylidene derivatives into the corresponding N-potassium salts, and their final N-acylation with acyl chlorides. The in vitro antitumor efficacy of the compounds was evaluated by the MTT method.

Funders

Basic Research Project of Heilongjiang Basic Scientific Research Operating Expenses

SZDYF202306

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