Keywords
Abramov reaction
Antibacterial activity
Antifungal activity
solvent free conditions
X-ray diffraction.
α-hydroxy phosphonates
Abstract
New dialkyl [(hydroxy)(4-nitrophenyl)methyl]phosphonates containing various alkyl substituents were obtained from 4-nitrobenzaldehyde and the corresponding dialkyl phosphites and demonstrated antibacterial activity against Gram-positive bacterial strains B. cereus and S. aureus and antifungal activity against Candida albicans fungi. The dependence of antimicrobial activity on the nature of the substituents at the carbon atom a to phosphorus has been established.
Funders
Russian Science Foundation
24-23-00328
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