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Fluorescent conjugates of PSMA-targeting ligand with cyanine dyes: synthetic approaches and photochemical properties

Anastasiia Alekseevna Uspenskaia 1
Anastasiia Alekseevna Uspenskaia
,  , 
Kseniia Aleksandrovna Popovicheva 2
Kseniia Aleksandrovna Popovicheva
, 
Nazar Vasilyvich Shmychkov 1
Nazar Vasilyvich Shmychkov
, 
Irina Ivanovna Levina 3
Irina Ivanovna Levina
, 
Mikhail Konstantinovich Beklemishev 1
Mikhail Konstantinovich Beklemishev
, 
Vadim Neronovich Tashlitsky 1
Vadim Neronovich Tashlitsky
, 
Tatyana Aleksandrovna Podrugina 1
Tatyana Aleksandrovna Podrugina
, 
Aleksei Eduardovich Machulkin 1, 4
Aleksei Eduardovich Machulkin
, 
Elena Kimovna Beloglazkina 1
Elena Kimovna Beloglazkina
3 N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russian Federation
4 Department for Biochemistry, People’s Friendship University of Russia (RUDN University), 117198, Moscow, Russian Federation
10.71267/mencom.7583
Published 2025-02-18
Communication , Volume 35, Issue 2, 172-175
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Uspenskaia A. A. et al. Fluorescent conjugates of PSMA-targeting ligand with cyanine dyes: synthetic approaches and photochemical properties // Mendeleev Communications. 2025. Vol. 35. No. 2. pp. 172-175.
GOST all authors (up to 50) Copy
Uspenskaia A. A., Doroshenko I. A., Popovicheva K. A., Shmychkov N. V., Levina I. I., Beklemishev M. K., Tashlitsky V. N., Podrugina T. A., Machulkin A. E., Beloglazkina E. K. Fluorescent conjugates of PSMA-targeting ligand with cyanine dyes: synthetic approaches and photochemical properties // Mendeleev Communications. 2025. Vol. 35. No. 2. pp. 172-175.
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TY - JOUR
DO - 10.71267/mencom.7583
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7583
TI - Fluorescent conjugates of PSMA-targeting ligand with cyanine dyes: synthetic approaches and photochemical properties
T2 - Mendeleev Communications
AU - Uspenskaia, Anastasiia Alekseevna
AU - Doroshenko, Irina Andreevna
AU - Popovicheva, Kseniia Aleksandrovna
AU - Shmychkov, Nazar Vasilyvich
AU - Levina, Irina Ivanovna
AU - Beklemishev, Mikhail Konstantinovich
AU - Tashlitsky, Vadim Neronovich
AU - Podrugina, Tatyana Aleksandrovna
AU - Machulkin, Aleksei Eduardovich
AU - Beloglazkina, Elena Kimovna
PY - 2025
DA - 2025/02/18
PB - Mendeleev Communications
SP - 172-175
IS - 2
VL - 35
ER -
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@article{2025_Uspenskaia,
author = {Anastasiia Alekseevna Uspenskaia and Irina Andreevna Doroshenko and Kseniia Aleksandrovna Popovicheva and Nazar Vasilyvich Shmychkov and Irina Ivanovna Levina and Mikhail Konstantinovich Beklemishev and Vadim Neronovich Tashlitsky and Tatyana Aleksandrovna Podrugina and Aleksei Eduardovich Machulkin and Elena Kimovna Beloglazkina},
title = {Fluorescent conjugates of PSMA-targeting ligand with cyanine dyes: synthetic approaches and photochemical properties},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7583},
number = {2},
pages = {172--175},
doi = {10.71267/mencom.7583}
}
MLA
Cite this
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Uspenskaia, Anastasiia Alekseevna, et al. “Fluorescent conjugates of PSMA-targeting ligand with cyanine dyes: synthetic approaches and photochemical properties.” Mendeleev Communications, vol. 35, no. 2, Feb. 2025, pp. 172-175. https://mendcomm.colab.ws/publications/10.71267/mencom.7583.

Keywords

1
2
3-triazoles
carboxamides
conjugates
CuAAC click reaction
cyanine dyes
peptide synthesis
photochemistry
prostate-specific membrane antigen.

Abstract

Fluorescent conjugates of carbocyanine dyes with a ligand selective to prostate-specific membrane antigen were accessed by either peptide synthesis or CuAAC methodology, with the latter being more promising. The introduction of a propargylamino moiety at the meso-position of the polymethine chain of the fluorophores afforded the alkyne counterparts for the CuAAC reaction toward the ligand bearing azido group. The photochemical studies showed that the quantum yields of the obtained conjugates exceeded those for the unmodified fluorophores by more than 20 times.

Funders

Russian Science Foundation
23-23-00297

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