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New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses

Olga Andreevna Zhupikova 1
Olga Andreevna Zhupikova
, 
Olga Ivanovna Yarovaya 1
Olga Ivanovna Yarovaya
, 
Mariya Konstantinovna Marenina 1
Mariya Konstantinovna Marenina
, 
Yulia Vladimirovna Meshkova 1
Yulia Vladimirovna Meshkova
, 
Svetlana Valer'evna Belenkaya 1, 2
Svetlana Valer'evna Belenkaya
, 
Dmitriy Nikolaevich Shcherbakov 1, 2
Dmitriy Nikolaevich Shcherbakov
, 
Anna Vladimirovna Zaykovskaya 2
Anna Vladimirovna Zaykovskaya
, 
Oleg Victorovich Pyankov 2
Oleg Victorovich Pyankov
, 
Vladimir Victorovich Zarubaev 3
Vladimir Victorovich Zarubaev
, 
Mikhail Gennad'evich Mikhalsky 3
Mikhail Gennad'evich Mikhalsky
, 
Alexey Yuryevich Fedorov 4
Alexey Yuryevich Fedorov
, 
Sergey Grigoryevich Arkhipov 4
Sergey Grigoryevich Arkhipov
, 
Vladimir Ivanovich Potkin 5
Vladimir Ivanovich Potkin
, 
Irina Andreevna Kolesnik 5
Irina Andreevna Kolesnik
,  , 
Nariman Faridovich Salakhutdinov 1
Nariman Faridovich Salakhutdinov
, 
Mikhail Vladimirovich Khvostov 1
Mikhail Vladimirovich Khvostov
2 State Research Center of Virology and Biotechnology ‘Vector’, 630559 Koltsovo, Novosibirsk Region, Russian Federation
3 St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russian Federationy
4 Institute of Chemical Technology, Novosibirsk State University, 630090 Novosibirsk, Russian Federation
5 Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
6 A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation
10.71267/mencom.7578
Published 2025-02-18
Communication , Volume 35, Issue 2, 145-147
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Zhupikova O. A. et al. New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses // Mendeleev Communications. 2025. Vol. 35. No. 2. pp. 145-147.
GOST all authors (up to 50) Copy
Zhupikova O. A., Yarovaya O. I., Marenina M. K., Meshkova Y. V., Belenkaya S. V., Shcherbakov D. N., Zaykovskaya A. V., Pyankov O. V., Zarubaev V. V., Mikhalsky M. G., Fedorov A. Y., Arkhipov S. G., Potkin V. I., Kolesnik I. A., Ivanov A. V., Salakhutdinov N. F., Khvostov M. V. New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses // Mendeleev Communications. 2025. Vol. 35. No. 2. pp. 145-147.
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TY - JOUR
DO - 10.71267/mencom.7578
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7578
TI - New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses
T2 - Mendeleev Communications
AU - Zhupikova, Olga Andreevna
AU - Yarovaya, Olga Ivanovna
AU - Marenina, Mariya Konstantinovna
AU - Meshkova, Yulia Vladimirovna
AU - Belenkaya, Svetlana Valer'evna
AU - Shcherbakov, Dmitriy Nikolaevich
AU - Zaykovskaya, Anna Vladimirovna
AU - Pyankov, Oleg Victorovich
AU - Zarubaev, Vladimir Victorovich
AU - Mikhalsky, Mikhail Gennad'evich
AU - Fedorov, Alexey Yuryevich
AU - Arkhipov, Sergey Grigoryevich
AU - Potkin, Vladimir Ivanovich
AU - Kolesnik, Irina Andreevna
AU - Ivanov, Andrey Viktorovich
AU - Salakhutdinov, Nariman Faridovich
AU - Khvostov, Mikhail Vladimirovich
PY - 2025
DA - 2025/02/18
PB - Mendeleev Communications
SP - 145-147
IS - 2
VL - 35
ER -
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@article{2025_Zhupikova,
author = {Olga Andreevna Zhupikova and Olga Ivanovna Yarovaya and Mariya Konstantinovna Marenina and Yulia Vladimirovna Meshkova and Svetlana Valer'evna Belenkaya and Dmitriy Nikolaevich Shcherbakov and Anna Vladimirovna Zaykovskaya and Oleg Victorovich Pyankov and Vladimir Victorovich Zarubaev and Mikhail Gennad'evich Mikhalsky and Alexey Yuryevich Fedorov and Sergey Grigoryevich Arkhipov and Vladimir Ivanovich Potkin and Irina Andreevna Kolesnik and Andrey Viktorovich Ivanov and Nariman Faridovich Salakhutdinov and Mikhail Vladimirovich Khvostov},
title = {New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7578},
number = {2},
pages = {145--147},
doi = {10.71267/mencom.7578}
}
MLA
Cite this
MLA Copy
Zhupikova, Olga Andreevna, et al. “New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses.” Mendeleev Communications, vol. 35, no. 2, Feb. 2025, pp. 145-147. https://mendcomm.colab.ws/publications/10.71267/mencom.7578.

Keywords

antiviral activity
biological activity.
influenza A (H1N1) virus
isoxazoles
protease 3Clpro
SARS-CoV-2 virus
tetrahydroindoles
thiosemicarbazones

Abstract

New thiosemicarbazones based on 5-arylisoxazole-3-carbaldehyde and substituted pyrrolecarbaldehydes have been obtained. The test for ability to inhibit the main viral protease 3Clpro of SARS-CoV-2 virus revealed a compound with activity against both corona- and influenza viruses.

Funders

Ministry of Education and Science of the Russian Federation
FWUE-2022- 0014

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