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Synthesis and antimicrobial activity of mono- and bisphosphonium salts based on tertiary phosphines and ethyl bromoacetate

Semyon R. Romanov 1
Semyon R. Romanov
, 
Olga V. Orlova 1
Olga V. Orlova
, 
Marina Petrovna Shulaeva 1, 2
Marina Petrovna Shulaeva
, 
Oskar Kimovich Pozdeev 2
Oskar Kimovich Pozdeev
, 
Anton P. Fedonin 1
Anton P. Fedonin
, 
Kamil A. Ivshin 3
Kamil A. Ivshin
, 
Olga N. Kataeva 3
Olga N. Kataeva
, 
Irina Vasil'evna Galkina 1
Irina Vasil'evna Galkina
, 
Yulia V. Bakhtiyarova 1
Yulia V. Bakhtiyarova
1 A. M. Butlerov Institute of Chemistry, Kazan Federal University, 420008 Kazan, Russian Federation
2 Kazan State Medical Academy, 420012 Kazan, Russian Federation
3 A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, 420088 Kazan, Russian Federation
10.71267/mencom.7560
Published 2025-01-24
Communication , Volume 35, Issue 1, 60-62
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Romanov S. R. et al. Synthesis and antimicrobial activity of mono- and bisphosphonium salts based on tertiary phosphines and ethyl bromoacetate // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 60-62.
GOST all authors (up to 50) Copy
Romanov S. R., Orlova O. V., Shulaeva M. P., Pozdeev O. K., Fedonin A. P., Ivshin K. A., Kataeva O. N., Galkina I. V., Bakhtiyarova Y. V. Synthesis and antimicrobial activity of mono- and bisphosphonium salts based on tertiary phosphines and ethyl bromoacetate // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 60-62.
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TY - JOUR
DO - 10.71267/mencom.7560
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7560
TI - Synthesis and antimicrobial activity of mono- and bisphosphonium salts based on tertiary phosphines and ethyl bromoacetate
T2 - Mendeleev Communications
AU - Romanov, Semyon R.
AU - Orlova, Olga V.
AU - Shulaeva, Marina Petrovna
AU - Pozdeev, Oskar Kimovich
AU - Fedonin, Anton P.
AU - Ivshin, Kamil A.
AU - Kataeva, Olga N.
AU - Galkina, Irina Vasil'evna
AU - Bakhtiyarova, Yulia V.
PY - 2025
DA - 2025/01/24
PB - Mendeleev Communications
SP - 60-62
IS - 1
VL - 35
ER -
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@article{2025_Romanov,
author = {Semyon R. Romanov and Olga V. Orlova and Marina Petrovna Shulaeva and Oskar Kimovich Pozdeev and Anton P. Fedonin and Kamil A. Ivshin and Olga N. Kataeva and Irina Vasil'evna Galkina and Yulia V. Bakhtiyarova},
title = {Synthesis and antimicrobial activity of mono- and bisphosphonium salts based on tertiary phosphines and ethyl bromoacetate},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jan},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7560},
number = {1},
pages = {60--62},
doi = {10.71267/mencom.7560}
}
MLA
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Romanov, Semyon R., et al. “Synthesis and antimicrobial activity of mono- and bisphosphonium salts based on tertiary phosphines and ethyl bromoacetate.” Mendeleev Communications, vol. 35, no. 1, Jan. 2025, pp. 60-62. https://mendcomm.colab.ws/publications/10.71267/mencom.7560.

Keywords

Antibacterial activity
antifungal activity.
bromoacetates
quaternary phosphonium salts
tertiary phosphines

Abstract

The nucleophilic substitution reaction between tertiary phosphines and ethyl bromoacetate affords the quaternary EtOC(O)CH2-substituted phosphonium salts. In the cases of bisphosphines, the corresponding bisphosphonium salts are formed. The synthesized phosphonium compounds were evaluated for in vitro antimicrobial activity.

Funders

Ministry of Education and Science of the Russian Federation

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