Home / Publications / Cyclodextrin increases the effectiveness of albumin’s interaction with antibacterial drugs and their combinations

Cyclodextrin increases the effectiveness of albumin’s interaction with antibacterial drugs and their combinations

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Elena Vadimovna Kudryashova 1
Elena Vadimovna Kudryashova
10.71267/mencom.7555
Published 2025-01-24
Communication , Volume 35, Issue 1, 76-78
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Skuredina A. A., Kudryashova E. V. Cyclodextrin increases the effectiveness of albumin’s interaction with antibacterial drugs and their combinations // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 76-78.
GOST all authors (up to 50) Copy
Skuredina A. A., Kudryashova E. V. Cyclodextrin increases the effectiveness of albumin’s interaction with antibacterial drugs and their combinations // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 76-78.
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TY - JOUR
DO - 10.71267/mencom.7555
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7555
TI - Cyclodextrin increases the effectiveness of albumin’s interaction with antibacterial drugs and their combinations
T2 - Mendeleev Communications
AU - Skuredina, Anna Alekseevna
AU - Kudryashova, Elena Vadimovna
PY - 2025
DA - 2025/01/24
PB - Mendeleev Communications
SP - 76-78
IS - 1
VL - 35
ER -
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@article{2025_Skuredina,
author = {Anna Alekseevna Skuredina and Elena Vadimovna Kudryashova},
title = {Cyclodextrin increases the effectiveness of albumin’s interaction with antibacterial drugs and their combinations},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jan},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7555},
number = {1},
pages = {76--78},
doi = {10.71267/mencom.7555}
}
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Skuredina, Anna Alekseevna, and Elena Vadimovna Kudryashova. “Cyclodextrin increases the effectiveness of albumin’s interaction with antibacterial drugs and their combinations.” Mendeleev Communications, vol. 35, no. 1, Jan. 2025, pp. 76-78. https://mendcomm.colab.ws/publications/10.71267/mencom.7555.

Keywords

antibacterial drug
cyclodextrin
fluorescence.
human serum albumin
non-covalent complex

Abstract

Fluorescence studies indicate that a two-drug combination demonstrates the synergism in binding to human serum albumin if drugs prefer different protein binding sites. The formation of a drug complex with methylated β-cyclodextrin leads to an increase in albumin’s quenching and drug binding affinity, while the fluorescence quenching mechanism remains unchanged.

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