Keywords
base
diethyl aminomalonate
dihydroindolizinones
nucleophilic addition
pyrrolylpropynoates
tetrahydroindolecarboxylate.
Abstract
3-(Pyrrol-2-yl)propynoates react with diethyl aminomalonate hydrochloride (excess Cs2CO3, reflux in MeCN, 6 h) to chemoselectively afford 8-amino-4-oxo-5,6-dihydroindolizine-7-carboxylates in good yields (62-85%).
Funders
Ministry of Education and Science of the Russian Federation
122041100031-5
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