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Synthesis, study of biological activity, and hemocompatibility of potential antitumor compounds of thiazolopyrimidinium systems

Olga Sergeevna Shemchuk 1, 2
Olga Sergeevna Shemchuk
, 
Boris Vladimirovich Paponov 1
Boris Vladimirovich Paponov
, 
Danil Aleksandrovich Rakitianskii 3
Danil Aleksandrovich Rakitianskii
, 
Dmitrii N. Kalyuzhny 4
Dmitrii N. Kalyuzhny
, 
Andrey Mikhailovich Rumyantsev 5
Andrey Mikhailovich Rumyantsev
, 
Elena V. Sambuk 5
Elena V. Sambuk
, 
Iliya М. Bublik 1
Iliya М. Bublik
, 
Polina V. Khomenko 1
Polina V. Khomenko
, 
Pavel A. Andoskin 1, 2
Pavel A. Andoskin
, 
Oleg Evgen'evich Molchanov 2
Oleg Evgen'evich Molchanov
,  , 
Konstantin Nikolaevich Semenov 1, 2
Konstantin Nikolaevich Semenov
, 
Vladimir Vladimirovich Sharoyko 1, 2
Vladimir Vladimirovich Sharoyko
1 I. P. Pavlov First St. Petersburg Medical University, 197002 St. Petersburg, Russian Federation
2 A. M. Granov Russian Research Center for Radiology and Surgical Technologies, 197758 St. Petersburg, Russian Federation
3 V. I. Chuikov Moscow South-Eastern School, 109457 Moscow, Russian Federation
4 V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russian Federation
5 Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russian Federation
10.71267/mencom.7540
Published 2025-01-24
Communication , Volume 35, Issue 1, 63-65
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Shemchuk O. S. et al. Synthesis, study of biological activity, and hemocompatibility of potential antitumor compounds of thiazolopyrimidinium systems // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 63-65.
GOST all authors (up to 50) Copy
Shemchuk O. S., Paponov B. V., Rakitianskii D. A., Kalyuzhny D. N., Rumyantsev A. M., Sambuk E. V., Bublik I. М., Khomenko P. V., Andoskin P. A., Molchanov O. E., Maistrenko D. N., Semenov K. N., Sharoyko V. V. Synthesis, study of biological activity, and hemocompatibility of potential antitumor compounds of thiazolopyrimidinium systems // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 63-65.
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TY - JOUR
DO - 10.71267/mencom.7540
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7540
TI - Synthesis, study of biological activity, and hemocompatibility of potential antitumor compounds of thiazolopyrimidinium systems
T2 - Mendeleev Communications
AU - Shemchuk, Olga Sergeevna
AU - Paponov, Boris Vladimirovich
AU - Rakitianskii, Danil Aleksandrovich
AU - Kalyuzhny, Dmitrii N.
AU - Rumyantsev, Andrey Mikhailovich
AU - Sambuk, Elena V.
AU - Bublik, Iliya М.
AU - Khomenko, Polina V.
AU - Andoskin, Pavel A.
AU - Molchanov, Oleg Evgen'evich
AU - Maistrenko, Dmitry Nikolaevich
AU - Semenov, Konstantin Nikolaevich
AU - Sharoyko, Vladimir Vladimirovich
PY - 2025
DA - 2025/01/24
PB - Mendeleev Communications
SP - 63-65
IS - 1
VL - 35
ER -
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@article{2025_Shemchuk,
author = {Olga Sergeevna Shemchuk and Boris Vladimirovich Paponov and Danil Aleksandrovich Rakitianskii and Dmitrii N. Kalyuzhny and Andrey Mikhailovich Rumyantsev and Elena V. Sambuk and Iliya М. Bublik and Polina V. Khomenko and Pavel A. Andoskin and Oleg Evgen'evich Molchanov and Dmitry Nikolaevich Maistrenko and Konstantin Nikolaevich Semenov and Vladimir Vladimirovich Sharoyko},
title = {Synthesis, study of biological activity, and hemocompatibility of potential antitumor compounds of thiazolopyrimidinium systems},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jan},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7540},
number = {1},
pages = {63--65},
doi = {10.71267/mencom.7540}
}
MLA
Cite this
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Shemchuk, Olga Sergeevna, et al. “Synthesis, study of biological activity, and hemocompatibility of potential antitumor compounds of thiazolopyrimidinium systems.” Mendeleev Communications, vol. 35, no. 1, Jan. 2025, pp. 63-65. https://mendcomm.colab.ws/publications/10.71267/mencom.7540.

Keywords

2-a]pyrimidin-4-ium salts
cytotoxic activity.
DNA
genotoxicity
hemolysis
Heterocycles
quaternized nitrogen
thiazolo[3

Abstract

Four novel antitumor agents, representatives of (E)-5-(4- dimethylaminostyryl)-7-methylthiazolo[3,2-a]pyrimidin-4-ium salts, were synthesized by sequential reactions of the corresponding aminothiazoles with acetylacetone and 4-dimethylaminobenzaldehyde. Cytotoxicity was assessed on five different cell lines (HeLa, PANC-1, A549, MCF-7, and ECV304). The results indicate that the salts have significant potential for further development as anticancer drugs.

Funders

Ministry of Health of the Russian Federation
EGISU: 1023022200055-4-3.2.21;3.1.3

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