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Synthesis and biological activity of thiazole--carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata

Dmitry Nikolaevich Pelageev 1
Dmitry Nikolaevich Pelageev
, 
Svetlana Mikhailovna Kovach 1, 2
Svetlana Mikhailovna Kovach
, 
Nadezhda Nikolaevna Balaneva 1
Nadezhda Nikolaevna Balaneva
, 
Yuri E. Sabutski 1
Yuri E. Sabutski
, 
Ksenia Leonidovna Borisova 1
Ksenia Leonidovna Borisova
, 
Ekaterina Sergeevna Menchinskaya 1
Ekaterina Sergeevna Menchinskaya
, 
Ekaterina Aleksandrovna Chingizova 1
Ekaterina Aleksandrovna Chingizova
, 
Artur R. Chingizov 1
Artur R. Chingizov
, 
Anna L. Burylova 3
Anna L. Burylova
, 
Oleg Yu. Slabko 2
Oleg Yu. Slabko
, 
Konstantin Anatol'evich Drozdov 1
Konstantin Anatol'evich Drozdov
, 
Victor Philippovich Anufriev 1
Victor Philippovich Anufriev
1 G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, 690022 Vladivostok, Russian Federation
2 Institute of High Technologies and Advanced Materials, Far Eastern Federal University, 690922 Vladivostok, Russian Federation
3 Institute of the World Ocean, Far Eastern Federal University, 690922 Vladivostok, Russian Federation
10.71267/mencom.7522
Published 2025-01-24
Communication , Volume 35, Issue 1, 66-68
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Pelageev D. N. et al. Synthesis and biological activity of thiazole--carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 66-68.
GOST all authors (up to 50) Copy
Pelageev D. N., Kovach S. M., Balaneva N. N., Sabutski Y. E., Borisova K. L., Menchinskaya E. S., Chingizova E. A., Chingizov A. R., Burylova A. L., Slabko O. Y., Drozdov K. A., Anufriev V. P. Synthesis and biological activity of thiazole--carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 66-68.
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TY - JOUR
DO - 10.71267/mencom.7522
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7522
TI - Synthesis and biological activity of thiazole--carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata
T2 - Mendeleev Communications
AU - Pelageev, Dmitry Nikolaevich
AU - Kovach, Svetlana Mikhailovna
AU - Balaneva, Nadezhda Nikolaevna
AU - Sabutski, Yuri E.
AU - Borisova, Ksenia Leonidovna
AU - Menchinskaya, Ekaterina Sergeevna
AU - Chingizova, Ekaterina Aleksandrovna
AU - Chingizov, Artur R.
AU - Burylova, Anna L.
AU - Slabko, Oleg Yu.
AU - Drozdov, Konstantin Anatol'evich
AU - Anufriev, Victor Philippovich
PY - 2025
DA - 2025/01/24
PB - Mendeleev Communications
SP - 66-68
IS - 1
VL - 35
ER -
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@article{2025_Pelageev,
author = {Dmitry Nikolaevich Pelageev and Svetlana Mikhailovna Kovach and Nadezhda Nikolaevna Balaneva and Yuri E. Sabutski and Ksenia Leonidovna Borisova and Ekaterina Sergeevna Menchinskaya and Ekaterina Aleksandrovna Chingizova and Artur R. Chingizov and Anna L. Burylova and Oleg Yu. Slabko and Konstantin Anatol'evich Drozdov and Victor Philippovich Anufriev},
title = {Synthesis and biological activity of thiazole--carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jan},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7522},
number = {1},
pages = {66--68},
doi = {10.71267/mencom.7522}
}
MLA
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Pelageev, Dmitry Nikolaevich, et al. “Synthesis and biological activity of thiazole--carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata.” Mendeleev Communications, vol. 35, no. 1, Jan. 2025, pp. 66-68. https://mendcomm.colab.ws/publications/10.71267/mencom.7522.

Keywords

bis(2-amino-4-phenyl-5-thiazolyl)disulfide
Polycarpa aurata.
polycarpine
thiacarpine
thioglycosides

Abstract

Based on bis(2-amino-4-phenyl-5-thiazolyl) disulfides, thiazole analogues of polycarpine, a cytotoxic alkaloid from the ascidian Polycarpa aurata, a wide range of thiazole--carbohydrate conjugates based on D-glucose and D-xylose has been obtained. Antitumor and antimicrobial activity for the synthesized compounds has been studied.

Funders

Russian Science Foundation
23-23-00357

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