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Structure--activity relationships of key bioantioxidants in reactions with radicals in DPPH, AAPH, and Hb--H2O2 systems

Vladimir Anatol'evich Volkov 1
Vladimir Anatol'evich Volkov
, 
Natalya N. Sazhina 1
Natalya N. Sazhina
, 
Mikhail Victorovich Voronkov 1
Mikhail Victorovich Voronkov
, 
Evgenya N Kuleshova 2
Evgenya N Kuleshova
1 N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russian Federation
10.71267/mencom.7466
Published 2025-01-24
Communication , Volume 35, Issue 1, 54-56
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Volkov V. A. et al. Structure--activity relationships of key bioantioxidants in reactions with radicals in DPPH, AAPH, and Hb--H2O2 systems // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 54-56.
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Volkov V. A., Sazhina N. N., Voronkov M. V., Kuleshova E. N. Structure--activity relationships of key bioantioxidants in reactions with radicals in DPPH, AAPH, and Hb--H2O2 systems // Mendeleev Communications. 2025. Vol. 35. No. 1. pp. 54-56.
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TY - JOUR
DO - 10.71267/mencom.7466
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7466
TI - Structure--activity relationships of key bioantioxidants in reactions with radicals in DPPH, AAPH, and Hb--H2O2 systems
T2 - Mendeleev Communications
AU - Volkov, Vladimir Anatol'evich
AU - Sazhina, Natalya N.
AU - Voronkov, Mikhail Victorovich
AU - Kuleshova, Evgenya N
PY - 2025
DA - 2025/01/24
PB - Mendeleev Communications
SP - 54-56
IS - 1
VL - 35
ER -
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@article{2025_Volkov,
author = {Vladimir Anatol'evich Volkov and Natalya N. Sazhina and Mikhail Victorovich Voronkov and Evgenya N Kuleshova},
title = {Structure--activity relationships of key bioantioxidants in reactions with radicals in DPPH, AAPH, and Hb--H2O2 systems},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jan},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7466},
number = {1},
pages = {54--56},
doi = {10.71267/mencom.7466}
}
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Volkov, Vladimir Anatol'evich, et al. “Structure--activity relationships of key bioantioxidants in reactions with radicals in DPPH, AAPH, and Hb--H2O2 systems.” Mendeleev Communications, vol. 35, no. 1, Jan. 2025, pp. 54-56. https://mendcomm.colab.ws/publications/10.71267/mencom.7466.

Keywords

antioxidants
ascorbic acid
chemiluminescence
DPPH
free radicals
gallic acid
glutathione
luminol
mexidol.
uric acid

Abstract

A comparative study of three systems based on various free radicals (AAPH azo initiator, hemoglobin--hydrogen peroxide, and DPPH) was performed by examining the kinetic and analytical properties of several significant bioantioxidants treated with these radicals. Common trends in structure--activity relationships for all three methods were shown. The measured data suggest a possibility of extrapolating the results obtained from one of the three methods to another when analyzing different chemical and biological objects.

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