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Solid-state properties of 1,2-epoxy-3-(2-cyanophenoxy)propane, a conglomerate-forming chiral drug precursor

Alexander Alexandrovich Bredikhin 1
Alexander Alexandrovich Bredikhin
, 
Zemfira Azal'evna Bredikhina 1
Zemfira Azal'evna Bredikhina
, 
Dmitry Victorovich Zakharychev 1
Dmitry Victorovich Zakharychev
, 
Flyura Serikovna Akhatova 1
Flyura Serikovna Akhatova
, 
Dmitry Borisovich Krivolapov 1
Dmitry Borisovich Krivolapov
, 
Igor Anatol'evich Litvinov 1
Igor Anatol'evich Litvinov
10.1070/MC2006v016n05ABEH002388
Published 2006-10-19
Communication , Volume 16, Issue 5, 245-247
7
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Bredikhin A. A. et al. Solid-state properties of 1,2-epoxy-3-(2-cyanophenoxy)propane, a conglomerate-forming chiral drug precursor // Mendeleev Communications. 2006. Vol. 16. No. 5. pp. 245-247.
GOST all authors (up to 50) Copy
Bredikhin A. A., Bredikhina Z. A., Zakharychev D. V., Akhatova F. S., Krivolapov D. B., Litvinov I. A. Solid-state properties of 1,2-epoxy-3-(2-cyanophenoxy)propane, a conglomerate-forming chiral drug precursor // Mendeleev Communications. 2006. Vol. 16. No. 5. pp. 245-247.
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TY - JOUR
DO - 10.1070/MC2006v016n05ABEH002388
UR - https://mendcomm.colab.ws/publications/10.1070/MC2006v016n05ABEH002388
TI - Solid-state properties of 1,2-epoxy-3-(2-cyanophenoxy)propane, a conglomerate-forming chiral drug precursor
T2 - Mendeleev Communications
AU - Bredikhin, Alexander Alexandrovich
AU - Bredikhina, Zemfira Azal'evna
AU - Zakharychev, Dmitry Victorovich
AU - Akhatova, Flyura Serikovna
AU - Krivolapov, Dmitry Borisovich
AU - Litvinov, Igor Anatol'evich
PY - 2006
DA - 2006/10/19
PB - Mendeleev Communications
SP - 245-247
IS - 5
VL - 16
ER -
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@article{2006_Bredikhin,
author = {Alexander Alexandrovich Bredikhin and Zemfira Azal'evna Bredikhina and Dmitry Victorovich Zakharychev and Flyura Serikovna Akhatova and Dmitry Borisovich Krivolapov and Igor Anatol'evich Litvinov},
title = {Solid-state properties of 1,2-epoxy-3-(2-cyanophenoxy)propane, a conglomerate-forming chiral drug precursor},
journal = {Mendeleev Communications},
year = {2006},
volume = {16},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1070/MC2006v016n05ABEH002388},
number = {5},
pages = {245--247},
doi = {10.1070/MC2006v016n05ABEH002388}
}
MLA
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Bredikhin, Alexander Alexandrovich, et al. “Solid-state properties of 1,2-epoxy-3-(2-cyanophenoxy)propane, a conglomerate-forming chiral drug precursor.” Mendeleev Communications, vol. 16, no. 5, Oct. 2006, pp. 245-247. https://mendcomm.colab.ws/publications/10.1070/MC2006v016n05ABEH002388.

Abstract

Both enantiomers of 1,2-epoxy-3-(2-cyanophenoxy)propane 1a were obtained and converted into enantiomeric bunitrolol hydrochlorides 3 to confirm the configuration of the formers; racemic 1a undergoes spontaneous resolution upon crystallization and could be resolved into individual enantiomers by a preferential crystallization with low efficiency.

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