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Zirconyl(IV) chloride: a novel and efficient reagent for the rapid synthesis of 1,5-benzodiazepines under solvent-free conditions

Rahul R Nagawade 1
Rahul R Nagawade
, 
Devanand B Shinde 2
Devanand B Shinde
10.1070/MC2006v016n02ABEH002171
Published 2006-04-14
Communication , Volume 16, Issue 2, 113-115
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Nagawade R. R., Shinde D. B. Zirconyl(IV) chloride: a novel and efficient reagent for the rapid synthesis of 1,5-benzodiazepines under solvent-free conditions // Mendeleev Communications. 2006. Vol. 16. No. 2. pp. 113-115.
GOST all authors (up to 50) Copy
Nagawade R. R., Shinde D. B. Zirconyl(IV) chloride: a novel and efficient reagent for the rapid synthesis of 1,5-benzodiazepines under solvent-free conditions // Mendeleev Communications. 2006. Vol. 16. No. 2. pp. 113-115.
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TY - JOUR
DO - 10.1070/MC2006v016n02ABEH002171
UR - https://mendcomm.colab.ws/publications/10.1070/MC2006v016n02ABEH002171
TI - Zirconyl(IV) chloride: a novel and efficient reagent for the rapid synthesis of 1,5-benzodiazepines under solvent-free conditions
T2 - Mendeleev Communications
AU - Nagawade, Rahul R
AU - Shinde, Devanand B
PY - 2006
DA - 2006/04/14
PB - Mendeleev Communications
SP - 113-115
IS - 2
VL - 16
ER -
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@article{2006_Nagawade,
author = {Rahul R Nagawade and Devanand B Shinde},
title = {Zirconyl(IV) chloride: a novel and efficient reagent for the rapid synthesis of 1,5-benzodiazepines under solvent-free conditions},
journal = {Mendeleev Communications},
year = {2006},
volume = {16},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1070/MC2006v016n02ABEH002171},
number = {2},
pages = {113--115},
doi = {10.1070/MC2006v016n02ABEH002171}
}
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Nagawade, Rahul R., and Devanand B Shinde. “Zirconyl(IV) chloride: a novel and efficient reagent for the rapid synthesis of 1,5-benzodiazepines under solvent-free conditions.” Mendeleev Communications, vol. 16, no. 2, Apr. 2006, pp. 113-115. https://mendcomm.colab.ws/publications/10.1070/MC2006v016n02ABEH002171.

Abstract

o-Phenylenediamines undergo rapid condensation with ketones having hydrogens at the α-position in the presence of 10 mol% zirconyl(IV) chloride under extremely mild reaction conditions to afford the corresponding 1,5-benzodiazepines in excellent yields with high selectivity. This method works well for both electron-rich as well as electron-deficient o-phenylenediamines.

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