Abstract
The reactions of 2-chloro-4-(substituted amino)-6-methyl-5-nitropyrimidine 1 with (L)-α-amino acids gave substituted derivatives 3, which were converted to optically active imidazo[1,2-a]pyrimidines 4 by treatment with either phosphorus oxychloride or polyphosphoric acid.
References
1.
Chern J., Lee C., Liaw Y., H.-J. Wang A.
Heterocycles,
1992
2.
10.1070/MC2005v015n04ABEH001994_bib2_1
Maruyama
Arzneim. -Forsch.,
1978
3.
10.1070/MC2005v015n04ABEH001994_bib2_2
Maruyama
Arzneim.-Forsch.,
1981
4.
RIVAL Y., GRASSY G., MICHEL G.
Chemical and Pharmaceutical Bulletin,
2011
5.
KATSURA Y., NISHINO S., INOUE Y., TOMOI M., TAKASUGI H.
Chemical and Pharmaceutical Bulletin,
2011
6.
Sanfilippo P.J., Urbanski M., Press J.B., Dubinsky B., Moore J.B.
Journal of Medicinal Chemistry,
1988
7.
Bakavoli M., Davoodnia A., Rahimizadeh M., Heravi M.M., Ghasemzadeh M.
Journal of Chemical Research,
2002
8.
Bakavoli M., Bakherad M., Rahimizadeh M., Heravi M.M.
Phosphorus, Sulfur and Silicon and the Related Elements,
2003
9.
Clark J., Varvounis G., Bakavoli M.
Journal of the Chemical Society Perkin Transactions 1,
1986
10.
Nagamatsu T., Hantani Y., Sasaki K., Ohtomo H., Nakayama T., Hirota T.
Journal of Heterocyclic Chemistry,
1993