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Synthesis of spirocyclic 4,5,5a,6,7,8-hexahydro-1H-pyrazolo[3,4-e]indolizine derivatives

Oleg Stanislavovich Eltsov 1
Oleg Stanislavovich Eltsov
, 
Elisaveta Vyacheslavovna D'yachenko 1
Elisaveta Vyacheslavovna D'yachenko
, 
Tatiana Vladimirovna Glukhareva 1
Tatiana Vladimirovna Glukhareva
, 
Yury Yur'evich Morzherin 1
Yury Yur'evich Morzherin
10.1070/MC2005v015n03ABEH002073
Published 4 May 2005 , received 20 October 2004
Communication , Volume 15, Issue 3, 119-120
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Eltsov O. S. et al. Synthesis of spirocyclic 4,5,5a,6,7,8-hexahydro-1H-pyrazolo[3,4-e]indolizine derivatives // Mendeleev Communications. 2005. Vol. 15. No. 3. pp. 119-120.
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Eltsov O. S., D'yachenko E. V., Glukhareva T. V., Morzherin Y. Y. Synthesis of spirocyclic 4,5,5a,6,7,8-hexahydro-1H-pyrazolo[3,4-e]indolizine derivatives // Mendeleev Communications. 2005. Vol. 15. No. 3. pp. 119-120.
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TY - JOUR
DO - 10.1070/MC2005v015n03ABEH002073
UR - https://mendcomm.colab.ws/publications/10.1070/MC2005v015n03ABEH002073
TI - Synthesis of spirocyclic 4,5,5a,6,7,8-hexahydro-1H-pyrazolo[3,4-e]indolizine derivatives
T2 - Mendeleev Communications
AU - Eltsov, Oleg Stanislavovich
AU - D'yachenko, Elisaveta Vyacheslavovna
AU - Glukhareva, Tatiana Vladimirovna
AU - Morzherin, Yury Yur'evich
PY - 2005
DA - 2005/05/04
PB - Mendeleev Communications
SP - 119-120
IS - 3
VL - 15
ER -
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@article{2005_Eltsov,
author = {Oleg Stanislavovich Eltsov and Elisaveta Vyacheslavovna D'yachenko and Tatiana Vladimirovna Glukhareva and Yury Yur'evich Morzherin},
title = {Synthesis of spirocyclic 4,5,5a,6,7,8-hexahydro-1H-pyrazolo[3,4-e]indolizine derivatives},
journal = {Mendeleev Communications},
year = {2005},
volume = {15},
publisher = {Mendeleev Communications},
month = {May},
url = {https://mendcomm.colab.ws/publications/10.1070/MC2005v015n03ABEH002073},
number = {3},
pages = {119--120},
doi = {10.1070/MC2005v015n03ABEH002073}
}
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Eltsov, Oleg Stanislavovich, et al. “Synthesis of spirocyclic 4,5,5a,6,7,8-hexahydro-1H-pyrazolo[3,4-e]indolizine derivatives.” Mendeleev Communications, vol. 15, no. 3, May. 2005, pp. 119-120. https://mendcomm.colab.ws/publications/10.1070/MC2005v015n03ABEH002073.
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Abstract

The condensation of 3-methyl-1-phenyl-5-pyrrolidinopyrazole-4-carboxaldehyde with N,N-dimethylbarbituric acid or Meldrum's acid followed by cyclization of the Knövenagel product by in a ‘tert-amino effect’ reaction resulted in the heterocyclic spiroderivatives of pyrazolo[3,4-e]indolizine.

References

1.
Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles
Ranatunge R.R., Garvey D.S., Janero D.R., Letts L.G., Martino A.M., Murty M.G., Richardson S.K., Young D.V., Zemetseva I.S.
Bioorganic and Medicinal Chemistry, 2004
2.
The development of new bicyclic pyrazole-based cytokine synthesis inhibitors
Townes J.A., Golebiowski A., Clark M.P., Laufersweiler M.J., Brugel T.A., Sabat M., Bookland R.G., Laughlin S.K., VanRens J.C., De B., Hsieh L.C., Xu S.C., Janusz M.J., Walter R.L.
Bioorganic and Medicinal Chemistry Letters, 2004
3.
Tricyclic Pyrazoles. Part 1: Synthesis and Biological Evaluation of Novel 1,4-Dihydroindeno[1,2-c]pyrazol-based Ligands for CB1and CB2 Cannabinoid Receptors
Mussinu J., Ruiu S., Mulè A.C., Pau A., Carai M.A., Loriga G., Murineddu G., Pinna G.A.
Bioorganic and Medicinal Chemistry, 2003
5.
10.1070/MC2005v015n03ABEH002073_bib5
Glukhareva
Khim. Geterotsikl. Soedin., 2002
6.
10.1070/MC2005v015n03ABEH002073_bib6
Elias
J. Mol. Struct. (Theochem.), 2003
7.
10.1070/MC2005v015n03ABEH002073_bib7
D’yachenko
Khim. Geterotsikl. Soedin., 2003
8.
10.1070/MC2005v015n03ABEH002073_bib8
D’yachenko
Izv. Akad. Nauk, Ser. Khim., 2004