Home / Publications / Simple synthesis of 4-aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones by the alkaline hydrolysis of Biginelli compounds

Simple synthesis of 4-aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones by the alkaline hydrolysis of Biginelli compounds

Anatoly Dmitrievich Shutalev 1
Anatoly Dmitrievich Shutalev
, 
Alexey N Aksenov 1
Alexey N Aksenov
10.1070/MC2005v015n02ABEH002023
Published 2005-03-23
Communication , Volume 15, Issue 2, 73-75
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Shutalev A. D., Aksenov A. N. Simple synthesis of 4-aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones by the alkaline hydrolysis of Biginelli compounds // Mendeleev Communications. 2005. Vol. 15. No. 2. pp. 73-75.
GOST all authors (up to 50) Copy
Shutalev A. D., Aksenov A. N. Simple synthesis of 4-aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones by the alkaline hydrolysis of Biginelli compounds // Mendeleev Communications. 2005. Vol. 15. No. 2. pp. 73-75.
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TY - JOUR
DO - 10.1070/MC2005v015n02ABEH002023
UR - https://mendcomm.colab.ws/publications/10.1070/MC2005v015n02ABEH002023
TI - Simple synthesis of 4-aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones by the alkaline hydrolysis of Biginelli compounds
T2 - Mendeleev Communications
AU - Shutalev, Anatoly Dmitrievich
AU - Aksenov, Alexey N
PY - 2005
DA - 2005/03/23
PB - Mendeleev Communications
SP - 73-75
IS - 2
VL - 15
ER -
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@article{2005_Shutalev,
author = {Anatoly Dmitrievich Shutalev and Alexey N Aksenov},
title = {Simple synthesis of 4-aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones by the alkaline hydrolysis of Biginelli compounds},
journal = {Mendeleev Communications},
year = {2005},
volume = {15},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1070/MC2005v015n02ABEH002023},
number = {2},
pages = {73--75},
doi = {10.1070/MC2005v015n02ABEH002023}
}
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Shutalev, Anatoly Dmitrievich, and Alexey N Aksenov. “Simple synthesis of 4-aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones by the alkaline hydrolysis of Biginelli compounds.” Mendeleev Communications, vol. 15, no. 2, Mar. 2005, pp. 73-75. https://mendcomm.colab.ws/publications/10.1070/MC2005v015n02ABEH002023.

Abstract

4-Aryl-6-styryl-1,2,3,4-tetrahydropyrimidin-2-ones are final products of transformation of ethyl 4-aryl-6-methyl-2-oxo-1,2,3,4- tetrahydropyrimidine-5-carboxylates in alkaline hydrolytic conditions.

References

1.
Ueber Aldehyduramide des Acetessigäthers
Biginelli P.
Berichte der deutschen chemischen Gesellschaft, 1891
2.
10.1070/MC2005v015n02ABEH002023_bib2
Biginelli
Gazz. Chim. Ital., 1893
3.
Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents
Atwal K.S., Swanson B.N., Unger S.E., Floyd D.M., Moreland S., Hedberg A., O'Reilly B.C.
Journal of Medicinal Chemistry, 1991
4.
Pharmacologic Profile of the Dihydropyrimidine Calcium Channel Blockers SQ 32,547 and SQ 32,946
Grover G.J., Dzwonczyk S., McMullen D.M., Normandin D.E., Parham C.S., Sleph P.G., Moreland S.
Journal of Cardiovascular Pharmacology, 2006
5.
Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis
Haggarty S.J., Mayer T.U., Miyamoto D.T., Fathi R., King R.W., Mitchison T.J., Schreiber S.L.
Chemistry & Biology, 2000
6.
Design and Synthesis of Novel α1a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones
Nagarathnam D., Miao S.W., Lagu B., Chiu G., Fang J., Murali Dhar T.G., Zhang J., Tyagarajan S., Marzabadi M.R., Zhang F., Wong W.C., Sun W., Tian D., Wetzel J.M., Forray C., et. al.
Journal of Medicinal Chemistry, 1999
10.
Expedient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones
Steele T.G., Coburn C.A., Patane M.A., Bock M.G.
Tetrahedron Letters, 1998
11.
RESEARCHES ON PYRIMIDINES. CXXX. SYNTHESIS OF 2-KETO-1,2,3,4-TETRAHYDROPYRIMIDINES
Folkers K., Harwood H.J., Johnson T.B.
Journal of the American Chemical Society, 1932
12.
Über Heterocyclen, 9. Mitt.: 2-Oxo-tetrahydropyrimidine, 1. Mitt.
Zigeuner G., Fuchs E., Galatik W.
Monatshefte fur Chemie, 1966