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Rational synthesis of all the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine

Oleg Victorovich Larionov 1
Oleg Victorovich Larionov
, 
Sergei Ivanovich Kozhushkov 1
Sergei Ivanovich Kozhushkov
, 
Melanie Brandl 1
Melanie Brandl
, 
Armin de Meijere 1
Armin de Meijere
10.1070/MC2003v013n05ABEH001817
Published 2003-11-04
Communication , Volume 13, Issue 5, 199-200
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Larionov O. V. et al. Rational synthesis of all the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine // Mendeleev Communications. 2003. Vol. 13. No. 5. pp. 199-200.
GOST all authors (up to 50) Copy
Larionov O. V., Kozhushkov S. I., Brandl M., de Meijere A. Rational synthesis of all the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine // Mendeleev Communications. 2003. Vol. 13. No. 5. pp. 199-200.
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TY - JOUR
DO - 10.1070/MC2003v013n05ABEH001817
UR - https://mendcomm.colab.ws/publications/10.1070/MC2003v013n05ABEH001817
TI - Rational synthesis of all the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine
T2 - Mendeleev Communications
AU - Larionov, Oleg Victorovich
AU - Kozhushkov, Sergei Ivanovich
AU - Brandl, Melanie
AU - de Meijere, Armin
PY - 2003
DA - 2003/11/04
PB - Mendeleev Communications
SP - 199-200
IS - 5
VL - 13
ER -
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@article{2003_Larionov,
author = {Oleg Victorovich Larionov and Sergei Ivanovich Kozhushkov and Melanie Brandl and Armin de Meijere},
title = {Rational synthesis of all the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine},
journal = {Mendeleev Communications},
year = {2003},
volume = {13},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1070/MC2003v013n05ABEH001817},
number = {5},
pages = {199--200},
doi = {10.1070/MC2003v013n05ABEH001817}
}
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Larionov, Oleg Victorovich, et al. “Rational synthesis of all the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine.” Mendeleev Communications, vol. 13, no. 5, Nov. 2003, pp. 199-200. https://mendcomm.colab.ws/publications/10.1070/MC2003v013n05ABEH001817.

Abstract

All the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine – a key constituent of the potential antitumor agent belactosin A – were prepared by simple catalytic hydrogenation of (2S,1'S,2'S)-, (2S,1’R,2’R)-, (2R,1’R,2’R)-, and (2R,1'S,2'S)-3-(trans-2-nitrocyclopropyl) alanines in 95, 93, 91 and 92% yields, respectively.

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