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One-step route to fluorinated furo[2,3-b]quinoxalines

, 
Galina Aleksandrovna Mokrushina 1
Galina Aleksandrovna Mokrushina
, 
Galina Mikhailovna Petrova 1
Galina Mikhailovna Petrova
, 
Grigori Grigorievich Alexandrov 1
Grigori Grigorievich Alexandrov
, 
Oleg Nikolaevich Chupakhin 2
Oleg Nikolaevich Chupakhin
10.1070/MC1998v008n04ABEH000973
Published 1998-09-10
Communication , Volume 8, Issue 4, 133-134
13
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Charushin V. N. et al. One-step route to fluorinated furo[2,3-b]quinoxalines // Mendeleev Communications. 1998. Vol. 8. No. 4. pp. 133-134.
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Charushin V. N., Mokrushina G. A., Petrova G. M., Alexandrov G. G., Chupakhin O. N. One-step route to fluorinated furo[2,3-b]quinoxalines // Mendeleev Communications. 1998. Vol. 8. No. 4. pp. 133-134.
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TY - JOUR
DO - 10.1070/MC1998v008n04ABEH000973
UR - https://mendcomm.colab.ws/publications/10.1070/MC1998v008n04ABEH000973
TI - One-step route to fluorinated furo[2,3-b]quinoxalines
T2 - Mendeleev Communications
AU - Charushin, Valery Nikolaevich
AU - Mokrushina, Galina Aleksandrovna
AU - Petrova, Galina Mikhailovna
AU - Alexandrov, Grigori Grigorievich
AU - Chupakhin, Oleg Nikolaevich
PY - 1998
DA - 1998/09/10
PB - Mendeleev Communications
SP - 133-134
IS - 4
VL - 8
ER -
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@article{1998_Charushin,
author = {Valery Nikolaevich Charushin and Galina Aleksandrovna Mokrushina and Galina Mikhailovna Petrova and Grigori Grigorievich Alexandrov and Oleg Nikolaevich Chupakhin},
title = {One-step route to fluorinated furo[2,3-b]quinoxalines},
journal = {Mendeleev Communications},
year = {1998},
volume = {8},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1070/MC1998v008n04ABEH000973},
number = {4},
pages = {133--134},
doi = {10.1070/MC1998v008n04ABEH000973}
}
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Charushin, Valery Nikolaevich, et al. “One-step route to fluorinated furo[2,3-b]quinoxalines.” Mendeleev Communications, vol. 8, no. 4, Sep. 1998, pp. 133-134. https://mendcomm.colab.ws/publications/10.1070/MC1998v008n04ABEH000973.

Abstract

The reaction of 6,7-difluoro-1-ethylquinoxalinium salts with 2,4-pentanedione, ethyl and bornyl acetoacetates and other β-keto esters results in the formation of 6,7-difluoro-3a,4,9,9a-tetrahydrofuro[2,3-b]quinoxalines. In addition, asymmetric 6-fluoro-7-morpholino and 6-fluoro-7-thiomorpholino substituted 1-ethylquinoxalinium salts react with alkyl acetoacetates in a regio- and stereoselective manner, thus giving exclusively the corresponding alkyl 2-methyl-6-fluoro-7-substituted 3a,4,9,9a-tetrahydrofuro[2,3-b]quinoxalin-3-carboxylates.

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