Home / Publications / Total synthesis of 20-hydroxy-hepoxilins, new metabolites of the hepoxilin family

Total synthesis of 20-hydroxy-hepoxilins, new metabolites of the hepoxilin family

Peter Mikhailovich Demin 1
Peter Mikhailovich Demin
, 
Tatjana A Manukina 1
Tatjana A Manukina
, 
Cecil R Pace-Asciak 2
Cecil R Pace-Asciak
, 
Kazimir Konstantinovich Pivnitsky 3
Kazimir Konstantinovich Pivnitsky
10.1070/MC1996v006n04ABEH000613
Published 1996-08-31
Communication , Volume 6, Issue 4, 130-132
6
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Demin P. M. et al. Total synthesis of 20-hydroxy-hepoxilins, new metabolites of the hepoxilin family // Mendeleev Communications. 1996. Vol. 6. No. 4. pp. 130-132.
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Demin P. M., Manukina T. A., Pace-Asciak C. R., Pivnitsky K. K. Total synthesis of 20-hydroxy-hepoxilins, new metabolites of the hepoxilin family // Mendeleev Communications. 1996. Vol. 6. No. 4. pp. 130-132.
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TY - JOUR
DO - 10.1070/MC1996v006n04ABEH000613
UR - https://mendcomm.colab.ws/publications/10.1070/MC1996v006n04ABEH000613
TI - Total synthesis of 20-hydroxy-hepoxilins, new metabolites of the hepoxilin family
T2 - Mendeleev Communications
AU - Demin, Peter Mikhailovich
AU - Manukina, Tatjana A
AU - Pace-Asciak, Cecil R
AU - Pivnitsky, Kazimir Konstantinovich
PY - 1996
DA - 1996/08/31
PB - Mendeleev Communications
SP - 130-132
IS - 4
VL - 6
ER -
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@article{1996_Demin,
author = {Peter Mikhailovich Demin and Tatjana A Manukina and Cecil R Pace-Asciak and Kazimir Konstantinovich Pivnitsky},
title = {Total synthesis of 20-hydroxy-hepoxilins, new metabolites of the hepoxilin family},
journal = {Mendeleev Communications},
year = {1996},
volume = {6},
publisher = {Mendeleev Communications},
month = {Aug},
url = {https://mendcomm.colab.ws/publications/10.1070/MC1996v006n04ABEH000613},
number = {4},
pages = {130--132},
doi = {10.1070/MC1996v006n04ABEH000613}
}
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Demin, Peter Mikhailovich, et al. “Total synthesis of 20-hydroxy-hepoxilins, new metabolites of the hepoxilin family.” Mendeleev Communications, vol. 6, no. 4, Aug. 1996, pp. 130-132. https://mendcomm.colab.ws/publications/10.1070/MC1996v006n04ABEH000613.

Abstract

A newly described enzymatically formed ω-hydroxy metabolite of hepoxilin A3 (HxA3) has been prepared via total synthesis involving polyacetylenic intermediates and Mitsunobu rearrangement of the intermediate putative ω-hydroxy metabolite of hepoxilin B3.

References

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D. Reynaud, O. Rounova, P. M. Demin, K. K. Pivnitsky and C. R. Pace-Asciak, to be published.
3.
Hepoxilins: a review on their cellular actions.
Pace-Asciak C.R.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1994
4.
A Chemoselective Synthesis of Functionalized 1,4-Alkadiynes (Skipped Diacetylenes)
Lapitskaya M.A., Vasiljeva L.L., Pivnitsky K.K.
Synthesis, 1993
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The Preparation and Synthetic Utility of tert-Butyldiphenylsilyl Ethers
Hanessian S., Lavallee P.
Canadian Journal of Chemistry, 1975
6.
Synthesis of methyl [5,6,8,9,14,-3 H6]-hepoxilin B3 and its conversion into methyl [5,6,8,9,14,15-3H6]-hepoxilin A3
Demin P.M., Pivnitsky K.K., Vasiljeva L.L., Pace-Asciak C.R.
Journal of Labelled Compounds and Radiopharmaceuticals, 1994
7.
Synthesis, properties, and identification of epimeric hepoxilins (−)-(10R)-B3 and (+)-(10S)-B3
Vasiljeva L.L., Manukina T.A., Demin P.M., Lapitskaja M.A., Pivnitsky K.K.
Tetrahedron, 1993