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A New Approach to the Synthesis of 1,2- and 1,4-Dihydropyrido[3,2-b]indole Derivatives

Svetlana Yur'evna Ryabova 1
Svetlana Yur'evna Ryabova
, 
Lyudmila Mikhailovna Alekseeva 1
Lyudmila Mikhailovna Alekseeva
, 
Vladimir Grigor'evich Granik 2
Vladimir Grigor'evich Granik
1 Centre for Medicinal Chemistry. Sergo Ordzhonikidze All-Russian Research Chemical-Pharmaceutical Institute, Moscow, Russian Federation
10.1070/MC1995v005n03ABEH000480
Published 1995-06-30
Communication , Volume 5, Issue 3, 107-109
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Ryabova S. Y., Alekseeva L. M., Granik V. G. A New Approach to the Synthesis of 1,2- and 1,4-Dihydropyrido[3,2-b]indole Derivatives // Mendeleev Communications. 1995. Vol. 5. No. 3. pp. 107-109.
GOST all authors (up to 50) Copy
Ryabova S. Y., Alekseeva L. M., Granik V. G. A New Approach to the Synthesis of 1,2- and 1,4-Dihydropyrido[3,2-b]indole Derivatives // Mendeleev Communications. 1995. Vol. 5. No. 3. pp. 107-109.
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TY - JOUR
DO - 10.1070/MC1995v005n03ABEH000480
UR - https://mendcomm.colab.ws/publications/10.1070/MC1995v005n03ABEH000480
TI - A New Approach to the Synthesis of 1,2- and 1,4-Dihydropyrido[3,2-b]indole Derivatives
T2 - Mendeleev Communications
AU - Ryabova, Svetlana Yur'evna
AU - Alekseeva, Lyudmila Mikhailovna
AU - Granik, Vladimir Grigor'evich
PY - 1995
DA - 1995/06/30
PB - Mendeleev Communications
SP - 107-109
IS - 3
VL - 5
ER -
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@article{1995_Ryabova,
author = {Svetlana Yur'evna Ryabova and Lyudmila Mikhailovna Alekseeva and Vladimir Grigor'evich Granik},
title = {A New Approach to the Synthesis of 1,2- and 1,4-Dihydropyrido[3,2-b]indole Derivatives},
journal = {Mendeleev Communications},
year = {1995},
volume = {5},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1070/MC1995v005n03ABEH000480},
number = {3},
pages = {107--109},
doi = {10.1070/MC1995v005n03ABEH000480}
}
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Ryabova, Svetlana Yur'evna, et al. “A New Approach to the Synthesis of 1,2- and 1,4-Dihydropyrido[3,2-b]indole Derivatives.” Mendeleev Communications, vol. 5, no. 3, Jun. 1995, pp. 107-109. https://mendcomm.colab.ws/publications/10.1070/MC1995v005n03ABEH000480.

Abstract

Intramolecular cyclization of α-cyano-β-(3-p-nitrophenylaminoindol-2-yl)acrylonitrile yields 1-p-nitrophenyl-2-imino-3-cyano-1,2-dihydropyrido[3,2-b]indole 7, methylation of which by methyl iodide in acetone in the presence of potassium carbonate is accompanied by the addition of acetonyl anion and formation of 1-p-nitrophenyl-2-dimethylamino-3-cyano-4-acetonyl-1,4-dihydropyrido[3,2-b]indole 9.

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