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Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium

Valery Nikolaevich Kalinin ¹

Valery Nikolaevich Kalinin

Irina Leonidovna Belyakova ¹

Irina Leonidovna Belyakova

Vladimir Vladimirovich Derunov ¹

Vladimir Vladimirovich Derunov

Jin K Park ²

Jin K Park

Helmut Schmidhammer ³

Helmut Schmidhammer

¹ A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

² Dong Kook Pharmaceutical Co., Ltd., Seoul, Korea

³ Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria

10.1070/MC1995v005n01ABEH000443

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Published 28 February 1995 , received 22 September 1994

Communication , Volume 5, Issue 1, 22-23

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Kalinin V. N. et al. Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium // Mendeleev Communications. 1995. Vol. 5. No. 1. pp. 22-23.

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Kalinin V. N., Belyakova I. L., Derunov V. V., Park J. K., Schmidhammer H. Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium // Mendeleev Communications. 1995. Vol. 5. No. 1. pp. 22-23.

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TY - JOUR

DO - 10.1070/MC1995v005n01ABEH000443

UR - https://mendcomm.colab.ws/publications/10.1070/MC1995v005n01ABEH000443

TI - Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium

T2 - Mendeleev Communications

AU - Kalinin, Valery Nikolaevich

AU - Belyakova, Irina Leonidovna

AU - Derunov, Vladimir Vladimirovich

AU - Park, Jin K

AU - Schmidhammer, Helmut

PY - 1995

DA - 1995/02/28

PB - Mendeleev Communications

SP - 22-23

IS - 1

VL - 5

ER -

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@article{1995_Kalinin,

author = {Valery Nikolaevich Kalinin and Irina Leonidovna Belyakova and Vladimir Vladimirovich Derunov and Jin K Park and Helmut Schmidhammer},

title = {Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium},

journal = {Mendeleev Communications},

year = {1995},

volume = {5},

publisher = {Mendeleev Communications},

month = {Feb},

url = {https://mendcomm.colab.ws/publications/10.1070/MC1995v005n01ABEH000443},

number = {1},

pages = {22--23},

doi = {10.1070/MC1995v005n01ABEH000443}

}

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Kalinin, Valery Nikolaevich, et al. “Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium.” Mendeleev Communications, vol. 5, no. 1, Feb. 1995, pp. 22-23. https://mendcomm.colab.ws/publications/10.1070/MC1995v005n01ABEH000443.

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Abstract

Treatment of 6β-chloro-6-deoxycodeine 1 with Pd(PPh₃)₄ yields 6-demethoxythebaine 2 and the π-allylic palladium complex 3, which further reacts with RZnX to give the cross-coupling product of the allylic ligand and R (compounds 5 and 6, respectively). The same products are formed upon reaction of 6β-chloro-6-deoxycodeine 1 with RZnX in the presence of catalytic amounts of Pd(PPh₃)₄.