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The Synthesis of Fluorinated 4H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin

Victor Igorevich Vysokov 1
Victor Igorevich Vysokov
,  , 
Galina B Afanasyeva 1
Galina B Afanasyeva
, 
Oleg Nikolaevich Chupakhin 3
Oleg Nikolaevich Chupakhin
10.1070/MC1993v003n04ABEH000267
Published 1993-08-31
Communication , Volume 3, Issue 4, 159-160
7
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Vysokov V. I. et al. The Synthesis of Fluorinated 4H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin // Mendeleev Communications. 1993. Vol. 3. No. 4. pp. 159-160.
GOST all authors (up to 50) Copy
Vysokov V. I., Charushin V. N., Afanasyeva G. B., Chupakhin O. N. The Synthesis of Fluorinated 4H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin // Mendeleev Communications. 1993. Vol. 3. No. 4. pp. 159-160.
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TY - JOUR
DO - 10.1070/MC1993v003n04ABEH000267
UR - https://mendcomm.colab.ws/publications/10.1070/MC1993v003n04ABEH000267
TI - The Synthesis of Fluorinated 4H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin
T2 - Mendeleev Communications
AU - Vysokov, Victor Igorevich
AU - Charushin, Valery Nikolaevich
AU - Afanasyeva, Galina B
AU - Chupakhin, Oleg Nikolaevich
PY - 1993
DA - 1993/08/31
PB - Mendeleev Communications
SP - 159-160
IS - 4
VL - 3
ER -
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@article{1993_Vysokov,
author = {Victor Igorevich Vysokov and Valery Nikolaevich Charushin and Galina B Afanasyeva and Oleg Nikolaevich Chupakhin},
title = {The Synthesis of Fluorinated 4H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin},
journal = {Mendeleev Communications},
year = {1993},
volume = {3},
publisher = {Mendeleev Communications},
month = {Aug},
url = {https://mendcomm.colab.ws/publications/10.1070/MC1993v003n04ABEH000267},
number = {4},
pages = {159--160},
doi = {10.1070/MC1993v003n04ABEH000267}
}
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Vysokov, Victor Igorevich, et al. “The Synthesis of Fluorinated 4H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin.” Mendeleev Communications, vol. 3, no. 4, Aug. 1993, pp. 159-160. https://mendcomm.colab.ws/publications/10.1070/MC1993v003n04ABEH000267.

Abstract

A synthetic route to 1,4-benzothiazine-2-carboxylic acid 1,1 -dioxides, analogues of the ‘fluoroquinolone’ family of antibacterials, has been developed; unfortunately, the target compound (the thia-analogue of pefloxacin) has not revealed remarkable antibacterial activity in vitro against the majority of the strains tested.

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