Abstract
The transformation of ‘Dimebon’, a γ-carboline derivative, has been accomplished by Penicillium simplicissimum and involves dehydrogenation of the γ-carboline ring, followed by N-demethylation, formation of a carbonyl group at C-4 and N-acetylation.
References
1.
Betts R.E., Walters D.E., Rosazza J.P.
Journal of Medicinal Chemistry,
1974
2.
Smith R.V., Rosazza J.P.
Archives of Biochemistry and Biophysics,
1974
3.
10.1070/MC1991v001n02ABEH000024_bib3
Feldman
Proc 4th Interscience Conf. Antimicrob. Agents Chemother,
1965
4.
10.1070/MC1991v001n02ABEH000024_bib4
Kost
Khim. Geterotsikl. Soedin.,
1973
5.
Neef G., Eder U., Petzoldt K., Seeger A., Wieglepp H.
Journal of the Chemical Society Chemical Communications,
1982
6.
10.1070/MC1991v001n02ABEH000024_bib6
Vorob’eva
Biotekhnologiya.,
1990
7.
I. A. Parshikov, L. V. Modyanova, E. V. Dovgilevich, P. B. Terent’ev, L. I. Vorob’eva and G. V. Grishina, Khim. Geterotsikl. Soedin., in the press.
8.
10.1070/MC1991v001n02ABEH000024_bib8
Kieslich
FEMS Symp.,
1978
9.
10.1070/MC1991v001n02ABEH000024_bib9
Hawkins
Biotransformations,
1989
10.
10.1070/MC1991v001n02ABEH000024_bib10
Kieslich
Microbial Transformation of Non-Steroid Cyclic Compounds,
1976