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Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid

Anna Mikhailovna Inshakova 1
Anna Mikhailovna Inshakova
, 
Vasily Andreevich Shchelkonogov 1, 2
Vasily Andreevich Shchelkonogov
, 
Natalia Sergeevna Shastina 1
Natalia Sergeevna Shastina
, 
Andrey Vasil'evich Chekanov 2
Andrey Vasil'evich Chekanov
, 
Olga Aleksandrovna Baranova 2
Olga Aleksandrovna Baranova
, 
Margarita O Sokolova 3
Margarita O Sokolova
, 
Anastasia Konstantinovna Ivanova 3
Anastasia Konstantinovna Ivanova
, 
Anatoly Ivanovich Fedin 2
Anatoly Ivanovich Fedin
, 
Ella Yur'evna Solov'eva 2
Ella Yur'evna Solov'eva
1 M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
2 N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
3 S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation
10.1016/j.mencom.2024.10.037
Published 2024-10-22
Communication , Volume 34, Issue 6, 887-889
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Inshakova A. M. et al. Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid // Mendeleev Communications. 2024. Vol. 34. No. 6. pp. 887-889.
GOST all authors (up to 50) Copy
Inshakova A. M., Shchelkonogov V. A., Shastina N. S., Chekanov A. V., Baranova O. A., Sokolova M. O., Ivanova A. K., Fedin A. I., Solov'eva E. Y. Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid // Mendeleev Communications. 2024. Vol. 34. No. 6. pp. 887-889.
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TY - JOUR
DO - 10.1016/j.mencom.2024.10.037
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.10.037
TI - Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid
T2 - Mendeleev Communications
AU - Inshakova, Anna Mikhailovna
AU - Shchelkonogov, Vasily Andreevich
AU - Shastina, Natalia Sergeevna
AU - Chekanov, Andrey Vasil'evich
AU - Baranova, Olga Aleksandrovna
AU - Sokolova, Margarita O
AU - Ivanova, Anastasia Konstantinovna
AU - Fedin, Anatoly Ivanovich
AU - Solov'eva, Ella Yur'evna
PY - 2024
DA - 2024/10/22
PB - Mendeleev Communications
SP - 887-889
IS - 6
VL - 34
ER -
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@article{2024_Inshakova,
author = {Anna Mikhailovna Inshakova and Vasily Andreevich Shchelkonogov and Natalia Sergeevna Shastina and Andrey Vasil'evich Chekanov and Olga Aleksandrovna Baranova and Margarita O Sokolova and Anastasia Konstantinovna Ivanova and Anatoly Ivanovich Fedin and Ella Yur'evna Solov'eva},
title = {Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.10.037},
number = {6},
pages = {887--889},
doi = {10.1016/j.mencom.2024.10.037}
}
MLA
Cite this
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Inshakova, Anna Mikhailovna, et al. “Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid.” Mendeleev Communications, vol. 34, no. 6, Oct. 2024, pp. 887-889. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.10.037.

Keywords

glutathione
lipoic acid
nanodispersions
neutrophils
platelets.

Abstract

To increase the therapeutic effectiveness of antioxidants (lipoic acid and glutathione) and improve their transport to target cells, various methods of modifying its substances are used. In this work, the synthesis of an amide derivative of lipoic acid and glutathione (GSH-LA) is performed, and GSH-LA nanodispersions based on Pluronic F68 are obtained. The most pronounced antioxidant and antiplatelet effects are exhibited by nanoparticles containing GSH-LA at the maximum tested concentration.

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