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An alternative synthesis of 7-amino-6-nitro-substituted azolo[1,5-a]pyrimidines

Ilya Igorevich Butorin 1
Ilya Igorevich Butorin
, 
Olga A Konovalova 1
Olga A Konovalova
, 
Pavel Alexandrovich Slepukhin 2
Pavel Alexandrovich Slepukhin
, 
Svetlana Konstantinovna Kotovskaya 1
Svetlana Konstantinovna Kotovskaya
, 
Vladimir Leonidovich Rusinov 1
Vladimir Leonidovich Rusinov
1 Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation
2 I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
10.1016/j.mencom.2024.09.026
Published 2024-09-09
Communication , Volume 34, Issue 5, 706-708
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Butorin I. I. et al. An alternative synthesis of 7-amino-6-nitro-substituted azolo[1,5-a]pyrimidines // Mendeleev Communications. 2024. Vol. 34. No. 5. pp. 706-708.
GOST all authors (up to 50) Copy
Butorin I. I., Konovalova O. A., Slepukhin P. A., Kotovskaya S. K., Rusinov V. L. An alternative synthesis of 7-amino-6-nitro-substituted azolo[1,5-a]pyrimidines // Mendeleev Communications. 2024. Vol. 34. No. 5. pp. 706-708.
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TY - JOUR
DO - 10.1016/j.mencom.2024.09.026
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.09.026
TI - An alternative synthesis of 7-amino-6-nitro-substituted azolo[1,5-a]pyrimidines
T2 - Mendeleev Communications
AU - Butorin, Ilya Igorevich
AU - Konovalova, Olga A
AU - Slepukhin, Pavel Alexandrovich
AU - Kotovskaya, Svetlana Konstantinovna
AU - Rusinov, Vladimir Leonidovich
PY - 2024
DA - 2024/09/09
PB - Mendeleev Communications
SP - 706-708
IS - 5
VL - 34
ER -
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@article{2024_Butorin,
author = {Ilya Igorevich Butorin and Olga A Konovalova and Pavel Alexandrovich Slepukhin and Svetlana Konstantinovna Kotovskaya and Vladimir Leonidovich Rusinov},
title = {An alternative synthesis of 7-amino-6-nitro-substituted azolo[1,5-a]pyrimidines},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.09.026},
number = {5},
pages = {706--708},
doi = {10.1016/j.mencom.2024.09.026}
}
MLA
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Butorin, Ilya Igorevich, et al. “An alternative synthesis of 7-amino-6-nitro-substituted azolo[1,5-a]pyrimidines.” Mendeleev Communications, vol. 34, no. 5, Sep. 2024, pp. 706-708. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.09.026.

Keywords

[1
2
4]triazolo[1
5-a]pyrimidines
acrylonitrile
DFT.
dinitropyridines
nitro synthons
pyrazolo[1

Abstract

New 7-amino-6-nitro-substituted [1,2,4]triazolo- and pyrazolo[1,5-a]pyrimidines were synthesized by an alternative strategy based on amino azoles and 2-nitro-3-(p-tolylamino)acrylonitrile. Unexpectedly, 3,5-dinitro-N-(p-tolyl)pyridine-2,6-diamine was formed when the starting 5-amino-1,2,4-triazoles contained NO2 or CF3 substituents.

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