Keywords
cell internalization
contrast agent
Eu-based luminescence.
fluorescent imaging
fluoride nanoparticle
hydrophilic coating
polymer
Abstract
This work introduces non-covalent hydrophilic coating of NaGd0.7Eu0.3F4 nanocrystals by polylysine (PL) and polyethyleneimine (PEI) for MRI and fluorescent imaging purposes. PL- and PEI-stabilized nanocrystals exhibit high colloidal stability, cell internalization, fluorescent contrasting of nuclei and cytoplasm, low cytotoxicity, and relaxivity (r1= 0.17 dm3 mmol-1 s-1 and r1 = 0.23 dm3 mmol-1 s-1).
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