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New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies

Van T.T. Tran 1
Van T.T. Tran
, 
Nhung Thi Dao 1
Nhung Thi Dao
, 
Thuyen T Do 1
Thuyen T Do
, 
Tam T.T Pham 2
Tam T.T Pham
, 
Duan The Le 1
Duan The Le
, 
Victor Nikolaevich Khrustalev 3, 4
Victor Nikolaevich Khrustalev
, 
Phuong T.T. Nguyen 5
Phuong T.T. Nguyen
, 
Anh Tuan Le 1
Anh Tuan Le
1 Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
2 Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, Vietnam
3 Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
5 Department of Training, FPT University, Hanoi, Vietnam
10.1016/j.mencom.2024.06.014
Published 2024-06-19
Communication , Volume 34, Issue 4, 514-517
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Tran V. T. et al. New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 514-517.
GOST all authors (up to 50) Copy
Tran V. T., Dao N. T., Do T. T., Pham T. T., Le D. T., Khrustalev V. N., Nguyen P. T., Le A. T. New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 514-517.
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TY - JOUR
DO - 10.1016/j.mencom.2024.06.014
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.014
TI - New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies
T2 - Mendeleev Communications
AU - Tran, Van T.T.
AU - Dao, Nhung Thi
AU - Do, Thuyen T
AU - Pham, Tam T.T
AU - Le, Duan The
AU - Khrustalev, Victor Nikolaevich
AU - Nguyen, Phuong T.T.
AU - Le, Anh Tuan
PY - 2024
DA - 2024/06/19
PB - Mendeleev Communications
SP - 514-517
IS - 4
VL - 34
ER -
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@article{2024_Tran,
author = {Van T.T. Tran and Nhung Thi Dao and Thuyen T Do and Tam T.T Pham and Duan The Le and Victor Nikolaevich Khrustalev and Phuong T.T. Nguyen and Anh Tuan Le},
title = {New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.014},
number = {4},
pages = {514--517},
doi = {10.1016/j.mencom.2024.06.014}
}
MLA
Cite this
MLA Copy
Tran, Van T.T., et al. “New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies.” Mendeleev Communications, vol. 34, no. 4, Jun. 2024, pp. 514-517. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.014.

Keywords

arylpyridine subunit
crown ring.
dithiaazacrown ethers
Hantzsch synthesis
Hep-G2

Abstract

New derivatives of dithiaazacrown ethers containing ψ-arylpyridine subunits were prepared based on the Hantzsch synthesis. The obtained compounds showed potential activities toward Hep-G2 cancer cell line, in both in silico and in vitro studies. The compounds were also good ligands for complex chemistry with metal ions due to possessing up to four heteroatoms and relatively big size of the crown ring.

References

.
Comparison of silver and molybdenum microfocus X-ray sources for single-crystal structure determination
Krause L., Herbst-Irmer R., Sheldrick G.M., Stalke D.
Journal of Applied Crystallography, 2015
.
Synthesis and molecular structure of bis(areno)piperidinoaza-14(17)-crowns-4(5)
Levov A.N., Le An’ T., Komarova A.I., Strokina V.M., Soldatenkov A.T., Khrustalev V.N.
Russian Journal of Organic Chemistry, 2008
.
Le T.A., Truong H.H., Thi T.P., Thi N.D., To H.T., Thi H.P., Soldatenkov A.T.
Mendeleev Communications, 2015
.
Synthesis and molecular structure of bis(benzo)aza-14-crown-4 ethers with 7-azabicyclo[3.3.1]nonane and homologous fragments
Levov A.N., Komarov A.I., Soldatenkov A.T., Avramenko G.V., Soldatova S.A., Khrustalev V.N.
Russian Journal of Organic Chemistry, 2008
.
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
Morris G.M., Huey R., Lindstrom W., Sanner M.F., Belew R.K., Goodsell D.S., Olson A.J.
Journal of Computational Chemistry, 2009
.
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Skehan P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Warren J.T., Bokesch H., Kenney S., Boyd M.R.
Journal of the National Cancer Institute, 1990
.
Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy
Wei H., Li Y., Xiao K., Cheng B., Wang H., Hu L., Zhai H.
Organic Letters, 2015
.
Supramolecular Based Membrane Sensors
Ganjali M., Norouzi P., Rezapour M., Faridbod F., Pourjavid M.
Sensors, 2006
.
Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications
Ullah F., Khan T.A., Iltaf J., Anwar S., Khan M.F., Khan M.R., Ullah S., Fayyaz ur Rehman M., Mustaqeem M., Kotwica-Mojzych K., Mojzych M.
Applied Sciences (Switzerland), 2022
.
Crown Ethers as Transthyretin Amyloidogenesis Inhibitors
Yokoyama T., Mizuguchi M.
Journal of Medicinal Chemistry, 2019
.
Cation-controlled catalysis with crown ether-containing transition metal complexes
Yoo C., Dodge H.M., Miller A.J.
Chemical Communications, 2019
.
Cytotoxic and Antimalarial Bisbenzylisoquinolme Alkaloids from Stephania erecta
Likhitwitayawuid K., Angerhofer C.K., Cordell G.A., Pezzuto J.M., Ruangrungsi N.
Journal of Natural Products, 1993
.
Synthesis of the first dibenzo-4,12-dithio-8-azacrownophanes containing γ-arylpyridine subunit
Thi T.T., Do T.T., Nguyen T.D., Luu V.B., Polyakova E.I., Thi T.V., Le T.A.
Chemistry of Heterocyclic Compounds, 2020
.
Synthesis, structural aspects, antimicrobial activity and ion transport investigation of five new [1+1] condensed cycloheterophane peptides
Zaim Ö., Aghatabay N.M., Gürbüz M.U., Baydar Ç., Dülger B.
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2013
.
FDA Drug Approval Summary: Erlotinib (Tarceva®) Tablets
Cohen M.H., Johnson J.R., Chen Y., Sridhara R., Pazdur R.
Oncologist, 2005
.
Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor
Jun K., Kwon H., Park S., Lee E., Karki R., Thapa P., Lee J., Lee E., Kwon Y.
European Journal of Medicinal Chemistry, 2014
.
Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study
Karki R., Thapa P., Yoo H.Y., Kadayat T.M., Park P., Na Y., Lee E., Jeon K., Cho W., Choi H., Kwon Y., Lee E.
European Journal of Medicinal Chemistry, 2012
.
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
Thapa P., Karki R., Yun M., Kadayat T.M., Lee E., Kwon H.B., Na Y., Cho W., Kim N.D., Jeong B., Kwon Y., Lee E.
European Journal of Medicinal Chemistry, 2012
.
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines
Karki R., Thapa P., Kang M.J., Jeong T.C., Nam J.M., Kim H., Na Y., Cho W., Kwon Y., Lee E.
Bioorganic and Medicinal Chemistry, 2010
.
Synthesis and Molecular Structure of Dibenzo [4-(α-Thienyl- and α-Pyrrolyl)pyrido]aza-14-crown-4 Ethers
Le A.T., Truong H.H., Nguyen P.T., Pham H.T., Kotsuba V.E., Soldatenkov A.T., Khrustalev V.N., Wodajo A.T.
Macroheterocycles, 2014
.
Nguyen D.T., Truong H.H., Dao N.T., Tran V.T., Gorchakova O.S., Le A.T.
Mendeleev Communications, 2023
.
Dao N.T., Do T.T., Pham T.T., Tran V.T., Khrustalev V.N., Le A.T.
Mendeleev Communications, 2023