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Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized via the azido-Ugi reaction

Anna Andreevna Smirnova 1
Anna Andreevna Smirnova
, 
Elena Valerievna Tretyakova 1
Elena Valerievna Tretyakova
, 
Oxana Borisovna Kazakova 1
Oxana Borisovna Kazakova
1 Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation
10.1016/j.mencom.2024.06.012
Published 2024-06-19
Communication , Volume 34, Issue 4, 509-510
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Smirnova A. A., Tretyakova E. V., Kazakova O. B. Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized via the azido-Ugi reaction // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 509-510.
GOST all authors (up to 50) Copy
Smirnova A. A., Tretyakova E. V., Kazakova O. B. Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized via the azido-Ugi reaction // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 509-510.
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TY - JOUR
DO - 10.1016/j.mencom.2024.06.012
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.012
TI - Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized via the azido-Ugi reaction
T2 - Mendeleev Communications
AU - Smirnova, Anna Andreevna
AU - Tretyakova, Elena Valerievna
AU - Kazakova, Oxana Borisovna
PY - 2024
DA - 2024/06/19
PB - Mendeleev Communications
SP - 509-510
IS - 4
VL - 34
ER -
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@article{2024_Smirnova,
author = {Anna Andreevna Smirnova and Elena Valerievna Tretyakova and Oxana Borisovna Kazakova},
title = {Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized via the azido-Ugi reaction},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.012},
number = {4},
pages = {509--510},
doi = {10.1016/j.mencom.2024.06.012}
}
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Smirnova, Anna Andreevna, et al. “Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized via the azido-Ugi reaction.” Mendeleev Communications, vol. 34, no. 4, Jun. 2024, pp. 509-510. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.012.

Keywords

abietane diterpenes
amino imides
anticancer activity.
azido-Ugi reaction
isocyanides
methyl maleopimarate
tetrazoles

Abstract

The azido-Ugi reaction of methyl maleopimarate N-(2- aminoethyl) imide with isocyanides, paraformaldehyde and trimethylsilyl azide in one step leads to 1,5-disubstituted diterpene bis-tetrazoles. The compounds demonstrate selective cytotoxicity against NCI-60 cancer cell panel.

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