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The homodimer approach to the design of a new long-acting depot prodrug of abiraterone

Evgeniya Vladimirovna Nurieva 1
Evgeniya Vladimirovna Nurieva
, 
Oxana Yur'evna Kravtsova 2
Oxana Yur'evna Kravtsova
, 
Anna V Sydoriuk 1
Anna V Sydoriuk
, 
Elena V Britikova 3
Elena V Britikova
, 
Vladimir V Britikov 3
Vladimir V Britikov
, 
Nikolay Alekseevich Zefirov 1
Nikolay Alekseevich Zefirov
,  , 
Ol'ga Nikolaevna Zefirova 1, 2
Ol'ga Nikolaevna Zefirova
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russian Federation
3 Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus
10.1016/j.mencom.2024.06.010
Published 2024-06-19
Communication , Volume 34, Issue 4, 502-504
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Nurieva E. V. et al. The homodimer approach to the design of a new long-acting depot prodrug of abiraterone // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 502-504.
GOST all authors (up to 50) Copy
Nurieva E. V., Kravtsova O. Y., Sydoriuk A. V., Britikova E. V., Britikov V. V., Zefirov N. A., Milaeva E. R., Zefirova O. N. The homodimer approach to the design of a new long-acting depot prodrug of abiraterone // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 502-504.
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TY - JOUR
DO - 10.1016/j.mencom.2024.06.010
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.010
TI - The homodimer approach to the design of a new long-acting depot prodrug of abiraterone
T2 - Mendeleev Communications
AU - Nurieva, Evgeniya Vladimirovna
AU - Kravtsova, Oxana Yur'evna
AU - Sydoriuk, Anna V
AU - Britikova, Elena V
AU - Britikov, Vladimir V
AU - Zefirov, Nikolay Alekseevich
AU - Milaeva, Elena Rudol'fovna
AU - Zefirova, Ol'ga Nikolaevna
PY - 2024
DA - 2024/06/19
PB - Mendeleev Communications
SP - 502-504
IS - 4
VL - 34
ER -
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@article{2024_Nurieva,
author = {Evgeniya Vladimirovna Nurieva and Oxana Yur'evna Kravtsova and Anna V Sydoriuk and Elena V Britikova and Vladimir V Britikov and Nikolay Alekseevich Zefirov and Elena Rudol'fovna Milaeva and Ol'ga Nikolaevna Zefirova},
title = {The homodimer approach to the design of a new long-acting depot prodrug of abiraterone},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.010},
number = {4},
pages = {502--504},
doi = {10.1016/j.mencom.2024.06.010}
}
MLA
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Nurieva, Evgeniya Vladimirovna, et al. “The homodimer approach to the design of a new long-acting depot prodrug of abiraterone.” Mendeleev Communications, vol. 34, no. 4, Jun. 2024, pp. 502-504. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.010.

Keywords

abiraterone prodrugs
citric acid
cytochrome P450 17A1 inhibitors
depot formulations
pimelic acid
plasma hydrolysis
prostate cancer.
steroid derivatives
succinic acid
twin drugs

Abstract

The synthesis of homodimeric bis-esters of abiraterone (an inhibitor of androgens synthesis used for treatment of prostate cancer) as a novel depot form of the drug intended for parenteral administration has been undertaken. The conjugate with succinic linker has been synthesized, while only mono-esters of malic and citric acid were obtained. The target ‘twin’ demonstrated excellent characteristics in preliminary biotests, proving the concept of long-lasting depot-prodrug.

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