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Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients

Ivan Mikhailovich Ryzhov 1
Ivan Mikhailovich Ryzhov
, 
Polina Sergeevna Obukhova 1, 2
Polina Sergeevna Obukhova
, 
Oxana Evgenievna Galanina 1
Oxana Evgenievna Galanina
, 
Eugenia Markovna Rapoport 1
Eugenia Markovna Rapoport
, 
Natalia Stanislavovna Egorova 1
Natalia Stanislavovna Egorova
, 
Nicolai Vladimirovich Bovin 1
Nicolai Vladimirovich Bovin
, 
Alexander Borisovich Tuzikov 1
Alexander Borisovich Tuzikov
1 M.M. Shemyakin-Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
2 National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Moscow, Russian Federation
10.1016/j.mencom.2024.06.009
Published 2024-06-19
Communication , Volume 34, Issue 4, 499-501
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Ryzhov I. M. et al. Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 499-501.
GOST all authors (up to 50) Copy
Ryzhov I. M., Obukhova P. S., Galanina O. E., Rapoport E. M., Egorova N. S., Bovin N. V., Tuzikov A. B. Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 499-501.
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TY - JOUR
DO - 10.1016/j.mencom.2024.06.009
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.009
TI - Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients
T2 - Mendeleev Communications
AU - Ryzhov, Ivan Mikhailovich
AU - Obukhova, Polina Sergeevna
AU - Galanina, Oxana Evgenievna
AU - Rapoport, Eugenia Markovna
AU - Egorova, Natalia Stanislavovna
AU - Bovin, Nicolai Vladimirovich
AU - Tuzikov, Alexander Borisovich
PY - 2024
DA - 2024/06/19
PB - Mendeleev Communications
SP - 499-501
IS - 4
VL - 34
ER -
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@article{2024_Ryzhov,
author = {Ivan Mikhailovich Ryzhov and Polina Sergeevna Obukhova and Oxana Evgenievna Galanina and Eugenia Markovna Rapoport and Natalia Stanislavovna Egorova and Nicolai Vladimirovich Bovin and Alexander Borisovich Tuzikov},
title = {Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.009},
number = {4},
pages = {499--501},
doi = {10.1016/j.mencom.2024.06.009}
}
MLA
Cite this
MLA Copy
Ryzhov, Ivan Mikhailovich, et al. “Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients.” Mendeleev Communications, vol. 34, no. 4, Jun. 2024, pp. 499-501. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.009.

Keywords

constrained peptide
FSL
human antibodies.
peptide epitope
protein S
pseudocyclic peptide
SARS-CoV-2

Abstract

An approach to the design of pseudocyclic peptide epitopes is proposed: lipid tails are attached to both C- and N-termini of the peptide through hydrophilic spacers; thanks to two lipid anchors, the conjugate is inserted into the membrane at two sites simultaneously, and the peptide becomes conformation- constrained. Despite the presence of two long lipid regions, the high hydrophilicity of the spacer makes the entire structure water-soluble, which is crucial for integration into living cells.

References

.
SARS-CoV-2 Peptide Bioconjugates Designed for Antibody Diagnostics
Ryzhov I.M., Tuzikov A.B., Nizovtsev A.V., Baidakova L.K., Galanina O.E., Shilova N.V., Ziganshina M.M., Dolgushina N.V., Bayramova G.R., Sukhikh G.T., Williams E.C., Nagappan R., Henry S.M., Bovin N.V.
Bioconjugate Chemistry, 2021
.
Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models
Kryukova E., Ivanov I., Lebedev D., Spirova E., Egorova N., Zouridakis M., Kasheverov I., Tzartos S., Tsetlin V.
Marine Drugs, 2018
.
Small and Simple, yet Sturdy: Conformationally Constrained Peptides with Remarkable Properties
Bozovičar K., Bratkovič T.
International Journal of Molecular Sciences, 2021
.
COVID ‐19 antibody screening with SARS‐CoV ‐2 red cell kodecytes using routine serologic diagnostic platforms
Nagappan R., Flegel W.A., Srivastava K., Williams E.C., Ryzhov I., Tuzikov A., Galanina O., Shilova N., Sukhikh G., Perry H., Bovin N.V., Henry S.M.
Transfusion, 2021
.
Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
Sesterhenn F., Galloux M., Vollers S.S., Csepregi L., Yang C., Descamps D., Bonet J., Friedensohn S., Gainza P., Corthésy P., Chen M., Rosset S., Rameix-Welti M., Éléouët J., Reddy S.T., et. al.
PLoS Biology, 2019
.
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen
Impagliazzo A., Milder F., Kuipers H., Wagner M.V., Zhu X., Hoffman R.M., van Meersbergen R., Huizingh J., Wanningen P., Verspuij J., de Man M., Ding Z., Apetri A., Kükrer B., Sneekes-Vriese E., et. al.
Science, 2015
.
Melikhova T.D., Bovin N.V., Antipov A.D., Tereshin M.N., Ziganshin R.H., Tuzikov A.B.
Mendeleev Communications, 2023