Home / Publications / A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography

A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography

Tat'yana F Savel'yeva 1
Tat'yana F Savel'yeva
, 
Zalina Taymurazovna Gugkaeva 1
Zalina Taymurazovna Gugkaeva
, 
Yulia Vladimirovna Nelyubina 1
Yulia Vladimirovna Nelyubina
, 
Alexander Fedorovich Smol'yakov 1
Alexander Fedorovich Smol'yakov
, 
Margarita Alekseevna Moskalenko 1
Margarita Alekseevna Moskalenko
, 
Vladimir Anatol'evich Larionov 1
Vladimir Anatol'evich Larionov
, 
1 A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
10.1016/j.mencom.2024.06.008
Published 2024-06-19
Communication , Volume 34, Issue 4, 496-498
4
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Savel'yeva T. F. et al. A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 496-498.
GOST all authors (up to 50) Copy
Savel'yeva T. F., Gugkaeva Z. T., Nelyubina Y. V., Smol'yakov A. F., Moskalenko M. A., Larionov V. A., Maleev V. I. A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography // Mendeleev Communications. 2024. Vol. 34. No. 4. pp. 496-498.
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TY - JOUR
DO - 10.1016/j.mencom.2024.06.008
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.008
TI - A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography
T2 - Mendeleev Communications
AU - Savel'yeva, Tat'yana F
AU - Gugkaeva, Zalina Taymurazovna
AU - Nelyubina, Yulia Vladimirovna
AU - Smol'yakov, Alexander Fedorovich
AU - Moskalenko, Margarita Alekseevna
AU - Larionov, Vladimir Anatol'evich
AU - Maleev, Victor Ivanovich
PY - 2024
DA - 2024/06/19
PB - Mendeleev Communications
SP - 496-498
IS - 4
VL - 34
ER -
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@article{2024_Savel'yeva,
author = {Tat'yana F Savel'yeva and Zalina Taymurazovna Gugkaeva and Yulia Vladimirovna Nelyubina and Alexander Fedorovich Smol'yakov and Margarita Alekseevna Moskalenko and Vladimir Anatol'evich Larionov and Victor Ivanovich Maleev},
title = {A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.008},
number = {4},
pages = {496--498},
doi = {10.1016/j.mencom.2024.06.008}
}
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Savel'yeva, Tat'yana F., et al. “A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography.” Mendeleev Communications, vol. 34, no. 4, Jun. 2024, pp. 496-498. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.06.008.

Keywords

18F-labelled amino acids
asymmetric synthesis
nickel(ii) complexes.
nucleophilic substitution
tyrosine

Abstract

New asymmetric metal-templated synthesis of enantiomers of (2S)- and (2R)-2-(3-[19F]fluoropropyl)tyrosine precursors were obtained based on a chiral NiII complex of the Schiff base derived from (S)-2-[N-(N’-benzylprolyl)amino]-benzaldehyde and racemic tyrosine in five steps. The free tyrosine derivatives which can be obtained upon decomplexation seem promising radiotracers for positron emission tomography imaging provided the introduction of 18F isotope.

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