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Polycomplexes to modulate bactericidal activity of cetylpyridinium bromide

Olga Alexandrovna Novoskoltseva
Darya Georgievna Sinelnikova 1
Darya Georgievna Sinelnikova
Nataliya G Loiko 2
Nataliya G Loiko
Yuriy Alexandrovich Nikolaev 2
Yuriy Alexandrovich Nikolaev
Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow, Russian Federation
Published 2024-04-22
CommunicationVolume 34, Issue 3, 369-371
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Novoskoltseva O. A. et al. Polycomplexes to modulate bactericidal activity of cetylpyridinium bromide // Mendeleev Communications. 2024. Vol. 34. No. 3. pp. 369-371.
GOST all authors (up to 50) Copy
Novoskoltseva O. A., Sinelnikova D. G., Loiko N. G., Nikolaev Y. A., Yaroslavov A. A. Polycomplexes to modulate bactericidal activity of cetylpyridinium bromide // Mendeleev Communications. 2024. Vol. 34. No. 3. pp. 369-371.
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TY - JOUR
DO - 10.1016/j.mencom.2024.04.018
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.04.018
TI - Polycomplexes to modulate bactericidal activity of cetylpyridinium bromide
T2 - Mendeleev Communications
AU - Novoskoltseva, Olga Alexandrovna
AU - Sinelnikova, Darya Georgievna
AU - Loiko, Nataliya G
AU - Nikolaev, Yuriy Alexandrovich
AU - Yaroslavov, Aleksandr Anatol'evich
PY - 2024
DA - 2024/04/22
PB - Mendeleev Communications
SP - 369-371
IS - 3
VL - 34
ER -
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@article{2024_Novoskoltseva,
author = {Olga Alexandrovna Novoskoltseva and Darya Georgievna Sinelnikova and Nataliya G Loiko and Yuriy Alexandrovich Nikolaev and Aleksandr Anatol'evich Yaroslavov},
title = {Polycomplexes to modulate bactericidal activity of cetylpyridinium bromide},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.04.018},
number = {3},
pages = {369--371},
doi = {10.1016/j.mencom.2024.04.018}
}
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Novoskoltseva, Olga Alexandrovna, et al. “Polycomplexes to modulate bactericidal activity of cetylpyridinium bromide.” Mendeleev Communications, vol. 34, no. 3, Apr. 2024, pp. 369-371. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.04.018.

Keywords

bactericides
biodegradable polymers
gram-negative bacteria
minimum inhibitory concentration.
polymer–surfactant complexes
pyridinium salts
quaternary ammonium compounds

Abstract

Cetylpyridinium bromide, a quaternary ammonium surfactant, was electrostatically complexed with an excess of anionic polymers such as biodegradable sodium alginate or non-biodegradable sodium polyacrylate. The binding of surfactant with alginate delivered polymer-surfactant complexes capable of killing both more surfactant-sensitive Escherichia coli and less surfactant-sensitive Pseudomonas aeruginosa bacteria, while the binding with acrylate gave complexes active only against Escherichia coli. The results obtained show a way for adjustment of the antimicrobial formulation to a specific pathogen to be destroyed.

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