Keywords
1
1 3-tropolone
8-naphthyridine
cytotoxic activity.
DFT
fluorescence
solid state emission
solvatochromism
X-ray diffraction analysis
Abstract
The acid-catalyzed reaction of 4-chloro-2,7-dimethyl- 1,8-naphthyridine with 4,6-di-tert-butyl-3-nitro-1,2-benzoquinone leads to new bis-1,3-tropolones. The crystal structures of the obtained bis-1,3-tropolones were determined by X-ray diffraction analysis; the spectral and luminescent properties, the structural and energy characteristics of the compounds were examined. The cytotoxic effect in vitro against cancer cell lines A549, H1299, HT29, CT26 and B16F10 was assessed using MTT assay.
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