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2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: synthesis, structure and in vitro study of the activity against influenza virus

Vasilii Vasil'evich Pelipko 1
Vasilii Vasil'evich Pelipko
, 
Igor Anatol'evich Litvinov 2
Igor Anatol'evich Litvinov
, 
Ekaterina Olegovna Sinegubova 3
Ekaterina Olegovna Sinegubova
, 
Vladimir Victorovich Zarubaev 3
Vladimir Victorovich Zarubaev
, 
Ruslan Izmailovich Baichurin 1
Ruslan Izmailovich Baichurin
, 
Sergey Valentinovich Makarenko 1
Sergey Valentinovich Makarenko
1 Herzen State Pedagogical University of Russia, St. Petersburg, Russian Federation
2 A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation
3 St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
10.1016/j.mencom.2024.02.031
Published 2024-02-19
Communication , Volume 34, Issue 2, 259-261
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Pelipko V. V. et al. 2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: synthesis, structure and in vitro study of the activity against influenza virus // Mendeleev Communications. 2024. Vol. 34. No. 2. pp. 259-261.
GOST all authors (up to 50) Copy
Pelipko V. V., Litvinov I. A., Sinegubova E. O., Zarubaev V. V., Baichurin R. I., Makarenko S. V. 2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: synthesis, structure and in vitro study of the activity against influenza virus // Mendeleev Communications. 2024. Vol. 34. No. 2. pp. 259-261.
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TY - JOUR
DO - 10.1016/j.mencom.2024.02.031
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.031
TI - 2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: synthesis, structure and in vitro study of the activity against influenza virus
T2 - Mendeleev Communications
AU - Pelipko, Vasilii Vasil'evich
AU - Litvinov, Igor Anatol'evich
AU - Sinegubova, Ekaterina Olegovna
AU - Zarubaev, Vladimir Victorovich
AU - Baichurin, Ruslan Izmailovich
AU - Makarenko, Sergey Valentinovich
PY - 2024
DA - 2024/02/19
PB - Mendeleev Communications
SP - 259-261
IS - 2
VL - 34
ER -
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@article{2024_Pelipko,
author = {Vasilii Vasil'evich Pelipko and Igor Anatol'evich Litvinov and Ekaterina Olegovna Sinegubova and Vladimir Victorovich Zarubaev and Ruslan Izmailovich Baichurin and Sergey Valentinovich Makarenko},
title = {2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: synthesis, structure and in vitro study of the activity against influenza virus},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.031},
number = {2},
pages = {259--261},
doi = {10.1016/j.mencom.2024.02.031}
}
MLA
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Pelipko, Vasilii Vasil'evich, et al. “2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: synthesis, structure and in vitro study of the activity against influenza virus.” Mendeleev Communications, vol. 34, no. 2, Feb. 2024, pp. 259-261. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.031.

Keywords

aza-Michael adduct
biological activity.
hydrazone
influenza A (H1N1) virus
N-phenylhydrazinecarboxamide
nitroacrylates
nucleophilic addition

Abstract

Alkyl (2E)-2-[2-(phenylcarbamoyl)hydrazinylidene]- propanoates were prepared from 3-nitroacrylates and N-phenylhydrazinecarboxamide. Their fine structure was confirmed by NMR and X-ray data. Cytotoxicity and antiviral activity against the A/Puerto Rico/8/34 (H1N1) influenza virus strain in MDCK cell culture were determined for the obtained compounds.

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