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Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)-H arylation of furan core under Pd/NHC-catalysis

Konstantin Evgen'evich Shepelenko 1
Konstantin Evgen'evich Shepelenko
, 
Irina Gennad'evna Gnatiuk 1
Irina Gennad'evna Gnatiuk
,  , 
Viktor Mikhailovich Chernyshev 1
Viktor Mikhailovich Chernyshev
1 Platov South-Russian State Polytechnic University, Novocherkassk, Russian Federation
10.1016/j.mencom.2024.02.012
Published 2024-02-19
Communication , Volume 34, Issue 2, 198-200
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Shepelenko K. E. et al. Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)-H arylation of furan core under Pd/NHC-catalysis // Mendeleev Communications. 2024. Vol. 34. No. 2. pp. 198-200.
GOST all authors (up to 50) Copy
Shepelenko K. E., Gnatiuk I. G., Minyaev M. E., Chernyshev V. M. Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)-H arylation of furan core under Pd/NHC-catalysis // Mendeleev Communications. 2024. Vol. 34. No. 2. pp. 198-200.
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TY - JOUR
DO - 10.1016/j.mencom.2024.02.012
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.012
TI - Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)-H arylation of furan core under Pd/NHC-catalysis
T2 - Mendeleev Communications
AU - Shepelenko, Konstantin Evgen'evich
AU - Gnatiuk, Irina Gennad'evna
AU - Minyaev, Mikhail Evgenievich
AU - Chernyshev, Viktor Mikhailovich
PY - 2024
DA - 2024/02/19
PB - Mendeleev Communications
SP - 198-200
IS - 2
VL - 34
ER -
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@article{2024_Shepelenko,
author = {Konstantin Evgen'evich Shepelenko and Irina Gennad'evna Gnatiuk and Mikhail Evgenievich Minyaev and Viktor Mikhailovich Chernyshev},
title = {Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)-H arylation of furan core under Pd/NHC-catalysis},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.012},
number = {2},
pages = {198--200},
doi = {10.1016/j.mencom.2024.02.012}
}
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Shepelenko, Konstantin Evgen'evich, et al. “Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)-H arylation of furan core under Pd/NHC-catalysis.” Mendeleev Communications, vol. 34, no. 2, Feb. 2024, pp. 198-200. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.012.

Keywords

3-c]quinolin-4(5H)-ones.
arylation
C–H activation
furo[2
N-heterocyclic carbene ligands
palladium

Abstract

An efficient procedure for the preparation of furo[2,3-c]-quinolin-4(5H)-ones from 2-furoic acid N-(o-bromoaryl)- amides via selective intramolecular C(3)-H arylation of the furan nucleus involves the catalysis by a Pd/NHC system generated in situ from Pd(OAc)2 and readily available IPrSPh HCl proligand. A series of novel furo[2,3-c]quinolin-4(5H)-ones were prepared in 65-80% isolated yields.

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