Home / Publications / Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl

Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl

, 
Alexandra Victorovna Posvyatenko 1, 2
Alexandra Victorovna Posvyatenko
, 
Alexey Sergeevich Galushko 1
Alexey Sergeevich Galushko
, 
Andrey Eduardovich Kolesnikov 1
Andrey Eduardovich Kolesnikov
2 Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
10.1016/j.mencom.2024.02.007
Published 2024-02-19
Communication , Volume 34, Issue 2, 181-184
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Egorova K. S. et al. Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl // Mendeleev Communications. 2024. Vol. 34. No. 2. pp. 181-184.
GOST all authors (up to 50) Copy
Egorova K. S., Posvyatenko A. V., Galushko A. S., Kolesnikov A. E. Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl // Mendeleev Communications. 2024. Vol. 34. No. 2. pp. 181-184.
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TY - JOUR
DO - 10.1016/j.mencom.2024.02.007
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.007
TI - Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl
T2 - Mendeleev Communications
AU - Egorova, Ksenia Sergeevna
AU - Posvyatenko, Alexandra Victorovna
AU - Galushko, Alexey Sergeevich
AU - Kolesnikov, Andrey Eduardovich
PY - 2024
DA - 2024/02/19
PB - Mendeleev Communications
SP - 181-184
IS - 2
VL - 34
ER -
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@article{2024_Egorova,
author = {Ksenia Sergeevna Egorova and Alexandra Victorovna Posvyatenko and Alexey Sergeevich Galushko and Andrey Eduardovich Kolesnikov},
title = {Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.007},
number = {2},
pages = {181--184},
doi = {10.1016/j.mencom.2024.02.007}
}
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Egorova, Ksenia Sergeevna, et al. “Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl.” Mendeleev Communications, vol. 34, no. 2, Feb. 2024, pp. 181-184. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.02.007.

Keywords

1'-biphenyl
4-methoxy-4'-nitro-1
bio-Profile
bio-Strip
C–C cross-coupling
cytotoxicity
cytotoxicity potential.
toxicity

Abstract

Using bio-Strips and cytotoxicity potentials, the least and most harmful substances involved in the synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl from 4-methoxyphenyl- boronic acid and aryl halide were identified. A total of 36 synthetic routes were analyzed.

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