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Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety

Dmitry Borisovich Shpakovsky 1
Dmitry Borisovich Shpakovsky
, 
Daria Artemovna Berseneva 1
Daria Artemovna Berseneva
, 
Yulia Aleksandrovna Gracheva 1
Yulia Aleksandrovna Gracheva
,  , 
Yurii Fedorovich Oprunenko 1
Yurii Fedorovich Oprunenko
, 
Vladimir V Britikov 2
Vladimir V Britikov
, 
Elena V Britikova 2
Elena V Britikova
, 
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus
10.1016/j.mencom.2024.01.007
Published 2023-12-25
Communication , Volume 34, Issue 1, 22-24
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Shpakovsky D. B. et al. Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety // Mendeleev Communications. 2023. Vol. 34. No. 1. pp. 22-24.
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Shpakovsky D. B., Berseneva D. A., Gracheva Y. A., Antonenko T. A., Oprunenko Y. F., Britikov V. V., Britikova E. V., Milaeva E. R. Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety // Mendeleev Communications. 2023. Vol. 34. No. 1. pp. 22-24.
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TY - JOUR
DO - 10.1016/j.mencom.2024.01.007
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.007
TI - Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety
T2 - Mendeleev Communications
AU - Shpakovsky, Dmitry Borisovich
AU - Berseneva, Daria Artemovna
AU - Gracheva, Yulia Aleksandrovna
AU - Antonenko, Taisiya Alekseevna
AU - Oprunenko, Yurii Fedorovich
AU - Britikov, Vladimir V
AU - Britikova, Elena V
AU - Milaeva, Elena Rudol'fovna
PY - 2023
DA - 2023/12/25
PB - Mendeleev Communications
SP - 22-24
IS - 1
VL - 34
ER -
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@article{2023_Shpakovsky,
author = {Dmitry Borisovich Shpakovsky and Daria Artemovna Berseneva and Yulia Aleksandrovna Gracheva and Taisiya Alekseevna Antonenko and Yurii Fedorovich Oprunenko and Vladimir V Britikov and Elena V Britikova and Elena Rudol'fovna Milaeva},
title = {Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety},
journal = {Mendeleev Communications},
year = {2023},
volume = {34},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.007},
number = {1},
pages = {22--24},
doi = {10.1016/j.mencom.2024.01.007}
}
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Shpakovsky, Dmitry Borisovich, et al. “Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety.” Mendeleev Communications, vol. 34, no. 1, Dec. 2023, pp. 22-24. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.007.
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Keywords

abiraterone
antiproliferative activity
apoptosis
cell cycle.
organotin complexes
prostate cancer

Abstract

Novel organotin(iv) complexes based on anticancer drug abiraterone acetate and abiraterone incorporating semipolar N→Sn bond at the pyridine moiety were synthesized and characterized. In vitro antiproliferative activity of the complexes against human cancer and normal cell lines was evaluated, the complexes with triphenyltin moiety being the most active (IC50 is in the range of 120-430 nm). Compounds actively induced apoptosis and blocked proliferation in the G2/M phase of the cell cycle.

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